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Effects of muscle relaxant E.M.P.P. on afferent discharges of muscle spindle in man--an microneurographic analysis

, : Effects of muscle relaxant E.M.P.P. on afferent discharges of muscle spindle in man--an microneurographic analysis. No to Shinkei 33(3): 237-241

Effects of a new muscle relaxant E.M.P.P.(4'-ethyl-2-methyl-3-piperidino-propiophenone . hydrochloride) on afferent discharges of muscle spindle were studied in 10 healthy volunteer subjects. Single unit afferent discharges of muscle spindle were recorded microneurographically from the median or tibial nerve using a tungsten microelectrode with a tip diameter of about 1 micrometer (impedence: about 10 M omega). Effects of an oral administration of 150--300 mg of E.M.P.P. on spontaneous afferent discharges as well as dynamic and static responses of muscle spindle were analysed in the present study. 1. E.M.P.P. suppressed remarkably the frequency of spontaneous afferent discharges of muscle spindle. Meanwhile, mental activations such as speech of mental arithmetic recovered temporarily the frequency of afferent discharges to that before E.M.P.P. administration. 2. E.M.P.P. suppressed the dynamic and static responses of muscle spindle to stretch. It also suppressed the dynamic responses of muscle spindle in the decontraction phase of electrically-induced twitch contractions of the receptor-bearing muscle. Based on these results, it is concluded that E.M.P.P. suppresses the static and dynamic activities of muscle spindle in man. These effects seem to be due to modifications of descending influences from central structures on the static and dynamic gamma motoneurons which innervate the muscle spindle.


PMID: 6454427

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Hubbard, R., 1966: The stereoisomerization of 11-cis-retinal. The thermodynamic parameters of the stereoisomerization of 11-cis-retinal to the all-trans configuration have been measured in n-heptane between 20 and 80[degree] (C). AF[free energy] =[long dash]1100 to[long dash]1400 cal mole-1, [DELTA]H = +150...

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Giudice, G.; Hörstadius, S., 1965: Effect of Actinomycin D on the segregation of animal and vegetal potentialities in the sea urchin egg. Experimental Cell Research 39(1): 117-120

Castaing Patrice, 1973: Utilization of factor analysis in sedimentology. Possibilities, includes examples using Q- or R-mode.

Scheibel E.; Ingerslev J.; Dalsgaard Nielsen J.; Stenbjerg S.; Knudsen J.B.; Dan Study Group, 1987: Continuous high dose factor viii for the induction of immune tolerance in hemophilia a patients with high responder state a description of eleven patients treated. Eleven severely affected haemophilia A patients (aged 6-42 y) with F VIII:C inhibitor (high responders) were treated with high-dose F VIII in order to eliminate the inhibitors. The patients comprise Danish high responder patients treated during th...

Gawrońska, I., 1969: Comparison of physiological tremor and tremor in patients with anterior horn cell disease. Polish Medical Journal 8(2): 444-450

Dressier, J.; Mach, P., 1967: Development of the activity of intracellular enzyme systems of piglet blood from birth to weaning. II. Alkaline phosphomonoesterase of neutrophiles. The alkaline phosphomonoesterase activity of the neutrophiles Was studied in 28 piglets from three litters of Large Whites from birth to 30 days. From the 16th day to the end of the experiment there was a significant rise. The correlation between...

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