+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of mutagenized X chromosomes of Drosophila melanogaster on viability and fitness in males

, : Effects of mutagenized X chromosomes of Drosophila melanogaster on viability and fitness in males. Environmental Mutagenesis 6(3): 261-272

Drosophila melanogaster males were treated with different doses of X-rays or ethyl methanesulfonate (EMS) and mated so that mutagenized X chromosomes could be recovered and tested for lethal mutations and for less drastic mutations affecting viability and other aspects of fitness. The lethals were detected in standard X-linked lethal tests. The less drastic mutations were detected in one generation tests for effects on viability and in multigeneration tests for effects on overall fitness. The Poisson-corrected frequencies of the lethal mutations increased linearly with dose for both X-rays and EMS. Based on the data, 1 Krad X-rays given acutely induces the same number of lethals as 0.55 mM EMS administered by feeding. For some of the X-ray and EMS doses, the mutagenized chromosomes that were nonlethal reduced the viability of their carriers by a small amount, but there was no discernable dose-effect relationship. However in every case where a viability effect was seen, the percentage reduction was less than the corresponding frequency of lethals. All the groups of mutagenized nonlethal chromosomes reduced overall fitness by a significant percentage. Wherever a meaningful comparison was possible, this reduction was 2-3 times the reduction in viability, but, as in the viability data, no dose-effect relationship was discernable.


PMID: 6428869

Other references

Scott, L., 1994: Air ambulances, hospitals renegotiate. Modern Healthcare 24(22): 32-32

Shi, H.; Zhang, Y.; Wang, L.; Li, X.; Li, W.; Wang, F.; Li, X., 2014: Molecular analysis of hyperthermophilic endoglucanase Cel12B from Thermotoga maritima and the properties of its functional residues. Although many hyperthermophilic endoglucanases have been reported from archaea and bacteria, a complete survey and classification of all sequences in these species from disparate evolutionary groups, and the relationship between their molecular st...

Plaksin, A.I., 1958: Changes of motor chronaxy in experimental tuberculosis in dogs in various types of higher nervous activity. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 2(2): 27-30

Pizza, G.; Chiodo, F.; Colangeli, V.; Gritti, F.; Raise, E.; Fudenberg, H.H.; D.V.nci, C.; Viza, D., 1996: Preliminary observations using HIV-specific transfer factor in AIDS. Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally with HIV-1-specific transfer factor (TF) for periods varying from 60 to 1870 days. All patients were receiving antiviral treatments in association with...

Benucci, M.; Nenci, G.; Taccetti, G.; Rosso, A.; Cappelletti, C., 2005: TRAPS syndrome, a rare cause of fever of unknown origin: case report and review of the literature. Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal dominant inherited condition of periodic fever and pain. TRAPS is caused by mutations of the TNFRSF1A gene localized at 12p13. The gene encodes extracellular...

Corcione, A.; Ferretti, E.; Pistoia, V., 2012: CX3CL1/fractalkine is a novel regulator of normal and malignant human B cell function. CX(3)CL1, or fractalkine, the unique member of the CX(3)C chemokine family, exists as a transmembrane glycoprotein, as well as in soluble form, each mediating different biological activities, and is constitutively expressed in many hematopoietic a...

Takaichi S.; Ishidsu J I.; Seki T.; Fukada S., 1990: Carotenoid pigments from rhodococcus rhodochrous rnms1 two monocyclic carotenoids a carotenoid monoglycoside and carotenoid glycoside monoesters. Four kinds of carotenoid pigments were found in Rhodococcus rhodochrous RNMS1. Spectroscopic and chemical evidence showed two of them to be monocyclic carotenoids each containing a tertiary hydroxyl group at C1', and their structures were det...

Frost Elton Jr.; Fertl Walter H., 1981: Integrated core and log analysis concepts in shaly clastic reservoirs. The Log Analyst 22(2): 3-16

Silander, K.; Tang, H.; Myles, S.; Jakkula, E.; Timpson, N.J.; Cavalli-Sforza, L.; Peltonen, L., 2009: Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease. A 100 kb region on 9p21.3 harbors two major disease susceptibility loci: one for type 2 diabetes (T2D) and one for coronary heart disease (CHD). The single nucleotide polymorphisms (SNPs) associated with these two diseases in Europeans reside on t...

Snegova, N.F.; Yurasova, A.S.; Ilyina, N.I., 2002: Investigation of Advantan clinical safety and efficacy for the treatment of atopic dermatitis in children. The study investigated the pharmacological basis for the application of the glucocorticoid-containing product Advantan (active ingredient methylprednisolone aceponate) as normal and fatty ointments, cream, and emulsion to the management of atopic...