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Effects of mycobacterial fractions and muramyl dipeptide on the resistance of mice to aerogenic influenza virus infection

, : Effects of mycobacterial fractions and muramyl dipeptide on the resistance of mice to aerogenic influenza virus infection. International Journal of Immunopharmacology 5(5): 403-410

The nonspecific protective effect in mice of pre-exposure to mycobacterial components and muramyl dipeptide three weeks before aerosol infection with influenza virus A/PR/8/34 (H1N1) was studied. Muramyl dipeptide, when combined with trehalose dimycolate and emulsified in an oil-in-water emulsion, conferred complete protection comparable to specific immunization with a high dose of formalin inactivated A/PR/8/34 influenza viral vaccine. Animals pre-exposed to muramyl dipeptide plus trehalose dimycolate showed a marked reduction in lung virus titres, an earlier clearance of detectable infectious virus, and an earlier onset of antibody production in comparison to control mice. Resistance to infection was also observed with BCG-cell wall skeleton combined with trehalose dimycolate and trehalose dimycolate alone when given as oil-in-water preparations. The route of administration of nonspecific stimulants was crucial. Only intravenous but not intradermal inoculation produced significant protection.


PMID: 6654538

Other references

Lavine, D.; Hurst, V.; Grossman, M.; Lee, M., 1965: Staphylococcus Of A Newly Recognized Bacteriophage Type: Report Of A Hospital Outbreak. JAMA 192: 935-938

Gimm, O., 2013: Extent of surgery in clinically evident but operable MTC - when is central and/or lateral lympadenectomy indicated?. Medullary thyroid carcinoma (MTC) metastasizes very early lymphogeneously. It has been shown that the presence of lymph node metastases is associated with a worse outcome. Postoperative biochemical cure, i.e. normalization of posttherapeutical cal...

Davis M.A., 1981: Preparation and in vivo stability of lead 203 di thiol complexes. Abstracts Of Papers American Chemical Society: Ucl 57

Cohen, Stanley, 1949: The nitrogenous metabolism of the earthwor. A study was made of the nitrogenous excretory products of well-nourished and starved earth-worms (Lumbricus terrestris). Well-nourished worms excreted ammonia mainly, with traces only of urea, uric acid, allantoin and allantoic acid. The formation...

Malecot, G., 1946: Consanguinity in a finite population. In a finite free-breeding population of N individuals, after the n th generation, there is a drift towards genetical homozygosity if the individuals are monecious or diecious. If N is a function of n, then the population tends to homozygosity if A...

Anonymous, 1972: Statistical appendix. Digest of data on the rheumatic diseases. 3. Handicap and disability, and international comparisons of morbidity and mortality. Annals of the Rheumatic Diseases 31(1): 72-77

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