geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nCPAP therapy on the blood picture in patients with obstructive sleep apnea


, : Effects of nCPAP therapy on the blood picture in patients with obstructive sleep apnea. Pneumologie 49(7): 413-417

In some patients with obstructive sleep apnea, changes in red blood cell count resembling polycythemia can be observed. If these changes result from the sleep-related breathing disorder, its adequate treatment should in turn induce a decrease of, for instance, hemoglobin concentration. We therefore set out by examining retrospectively the development of hemoglobin concentration under nCPAP in 130 patients with polysomnographically verified obstructive sleep apnea, comparing the values before treatment and after a mean of 12.0 months. During this period, hemoglobin mass concentration dropped from a mean of 153 +/- 13 g/Ls to 148 +/- 11 g/Ls (p < 0.001). Afterwards we prospectively examined in 50 patients the changes in complete blood cell count before and immediately after initiation of nCPAP treatment. It turned out that hemoglobin mass concentration dropped from a mean of 154 +/- 14 g/Ls to 148 +/- 14 g/Ls (p < 0.001), the erythrocyte count from 5.02 +/- 0.42/pl to 4.79 +/- 0.51/pl (p < 0.001), and hematocrit from 45.4 +/- 3.1% to 43.1 +/- 4.3% (p < 0.001) after only one night; no more significant change occurred after that. Increased hemoglobin mass concentrations, erythrocyte counts and hematocrit values can be the result of obstructive sleep apnea. Treatment of this sleep disorder with nCPAP will induce a quick and significant decrease of hemoglobin mass concentration, erythrocyte count, and hematocrit, independent of the initial values. This phenomenon points to the fact that changes in blood cell counts are not caused by a disturbance of erythropoesis but rather by alterations in volume regulation.

US$29.90

PMID: 7675756


Other references

Lehnert, S., 1979: Relationship of cyclic AMP levels to duration of radiation-induced mitotic delay. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine 36(4): 417-422

Abe, K., 1971: Some correlations between the findings of preoperative coronary arteriography and benefit of Vineberg's operation. Japanese Circulation Journal 35(5): 553-554

Martinez-Vázquez, J.M.; Miquel, C.; Pujol, R.; Vidal-Pla, R.; Esteban, R.; Roca, A., 1976: Pleural effusion in rheumatoid arthritis. Revista Clinica Espanola 142(1): 91-94

Mayton, M.R.; Carter, S.L.; Wheeler, J.J., 2014: Intrusiveness of behavioral treatments for adults with intellectual disability. The current study examined treatment intrusiveness within behavior intervention programs developed for adults with intellectual disability (ID). Behavior analysts provided demographic information about themselves, their adult clients with ID, and...

Jansen, J.P.; Warnier, AM., 2003: Assessment of 2001 aphid fly activity in Belgium with the help of a rothamsted suction trap Determination de lactivite des pucerons ailes a laide dun piege a succion resultants de lannee 2001. Results of alate aphids catches sampled in 2001 with the help of a Rothamsted suction trap are presented and analysed. Aphids catches were very low compared to previous years, indicating an strongly reduced aphid flight activity. Reduction was mar...

Ning, X-Hui.; Li, T.; Gong, Y-Qing.; He, Q.; Shen, Q.I.; Peng, S-He.; Wang, J-Yi.; Chen, J-Chao.; Guo, Y-Lu.; Gong, K., 2016: Association between FBP1 and hypoxia-related gene expression in clear cell renal cell carcinoma. NlmCategory="UNASSIGNED">Fructose-1,6-bisphosphatase 1 (FBP1) is a rate-limiting enzyme in gluconeogenesis. Recently, the catalytic activity-independent function of FBP1, hypoxia-induced factor (HIF) repression in the nucleus, was ide...

Higson, J.; Campbell, J.; Taylor, J., 2008: Day case surgery admission packs. Paediatric Nursing 20(5): 44-44

Kamei, J.; Ohsawa, M., 1998: Effects of streptozotocin-induced diabetes on place conditioning action of cocaine in mice. The effect of diabetes on the cocaine-induced place conditioning in mice was examined. In non-diabetic mice, cocaine, at dose ranges from 1 to 30 mg/kg, s.c. caused a dose-related preference for the drug-associated place, and significant place con...

Gibbons J.W.; Nelson S.Jr, 1968: Observations on the mudpuppy necturus maculosus in a michigan usa lake. American Midland Naturalist 80(2): 562-564

von Willebrand, E.; Lautenschlager, I.; Ahonen, J., 1989: Cellular activation in the graft and in blood during CMV disease. Transplantation Proceedings 21(1 Pt 2): 2080-2081