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Effects of nafenopin, diphenylhydantoin, phenobarbitone and some acetylenes on body composition: is there a relationship between decreased carcass lipid and increased liver size and induction of drug metabolizing enzymes?

, : Effects of nafenopin, diphenylhydantoin, phenobarbitone and some acetylenes on body composition: is there a relationship between decreased carcass lipid and increased liver size and induction of drug metabolizing enzymes?. International Journal of Obesity 4(1): 1-10

Administration of nafenopin, diphenylhydantoin, phenobarbitone or the acetylenes BRL 15268 and BRL 19001 in the diet or, in the case of phenobarbitone, in drinking water reduced the body-lipid content of genetically-obese (ob/ob) mice. These compounds also reduced food intake in ob/ob mice. However, dietary restriction had less effect on body-lipid content than did the compounds. Nafenopin, diphenylhydantoin and BRL 15268 reduced the body-lipid content of normal mice and had no effect on food intake. Each of the compounds that reduced body-lipid content increased the liver weight of normal and ob/ob mice. BRL 15268 and BRL 19001 increased the maximum activity of NADPH oxidase in liver. It is proposed that these reductions in body-lipid content result from the increased metabolic rate involved in enlarging the liver and maintaining its increased size.


PMID: 7390696

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Stinner, D., H.; Stinner, B., R.; Martsolf, E., 1997: Biodiversity as an organizing principle in agroecosystem management: Case studies of holistic resource management practitioners in the USA. Holistic Resource Management (HRM) is a process of goal setting, decision making and monitoring which integrates social, ecological and economic factors. Biodiversity enhancement is a fundamental principle in HRM and students are taught that biodi...

Diamandis, E.P.; Koupparis, M.A.; Hadjiioannou, T.P., 1977: Kinetic potentiometric determination of creatinine in urine with a picrate ion selective electrode. A new kinetic method for the potentiometric determination of creatinine in human urine based on the creatinine-picrate reaction in alkaline medium (Jaffe reaction) is described. The reaction is monitored with a picrate-selective electrode, and the...

Salomon, F.V.; Thuring, M.; Salomon, B., 1984: Influence of treadmill training on fibre type distribution and fibre diameter in semitendinosus muscle of swine. 24 pigs, 3 months old, were subjected to moving-belt tests: two 5-min stages with a 5-min interval, at a belt speed of 1 or 1.6 m/s, and blood lactate concentration was measured. They were then divided into 3 groups for 3 months' experiments:...

Waters, K.J., 1999: Clinical dilemma. A hernia sac cannot be found at operation. British Journal of Surgery 86(9): 1107-1107

Middleton, W.S., 1969: The evolution of modern cardiology, being in some measure the experience of a stethoscope (1908-1968). West Virginia Medical Journal 65(2): 31-38

Ginzburg, E.K.; Svishcheva, G.R.; Yudanin, A.Y.; Nesterova, T.B.; Zakiyan, S.M., 1993: Statistical analysis of the method of radiation mapping. This paper presents a modification of the method of Goss and Harris [Journal of Cell Science (1977) 25, 17] for the statistical analysis of data on radiation mapping of somatic hybrid cells. The method was applied to the case of 4 genes. Optimum s...

Fanara, D.M.; Knepper, R.G.; Ross, D.H., 1984: Field tests of two granular Bacillus thuringiensis (H-14) formulations against snowpool Aedes spp. Sand and maizecob granular formulations of Bacillus thuringiensis var. israelensis (Serotype H-14) applied to snow pools in Michigan in April 1982 and 1983, respectively, caused high larval mortality to larvae of Aedes spp., especially A. canadens...

Arneja, D.; Georgie, G.; Mehta, S.; Dixit, V.; Razdan, M., 1984: Plasma testosterone concentration in relation to thyroid status in Japanese quail. Indian journal of poultry science 19(4): 207-209

Charles A.D.; King A., 1985: Expression and secretion in escherichia coli of bovine growth hormone fused precisely to the signal sequence of beta lactamase. Journal of Cellular Biochemistry Supplement (9 PART B): 130

Park Charles Frederick Jr., 1935: Notes on the structure of the Erin shale of Alabama. Journal of the Washington Academy of Sciences 25(6): 276-279