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Effects of naftidrofuryl on the time course of the regional cerebral blood flow in acute ischemic stroke


, : Effects of naftidrofuryl on the time course of the regional cerebral blood flow in acute ischemic stroke. Arzneimittel-Forschung 34(11): 1580-1583

The effects of naftidrofuryl (LS-121), which is known as an activator of the cerebral glucose metabolism in addition to acting as a cerebral vasodilator on the regional cerebral blood flow (rCBF), were investigated in acute and subacute ischemic stroke patients. Six acute patients and 5 subacute patients were treated with 100-200 mg/day of naftidrofuryl for 7-14 days, and the rCBF was measured before and after the treatment by the 133Xe inhalation method. The hemispheric rCBF was significantly increased by 24% for the acute stage and 22% for the subacute stage in the affected side, compared with the stage-matched control group. Naftidrofuryl may accelerate the recovery of the rCBF of the affected hemisphere even in the acute stage.

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PMID: 6543134


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