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Effects of naloxone and its quarternary analogue on stimulation-induced feeding


, : Effects of naloxone and its quarternary analogue on stimulation-induced feeding. Neuropharmacology 22(1): 127-130

Feeding was induced in rats by electrical stimulation in the lateral hypothalamus. Naloxone (0.2 and 1.0 mg/kg) produced a dose-related elevation of the frequency threshold for stimulation-induced feeding while quarternary naloxone (2.0 and 10.0 mg/kg) had no effect. Since quarternary naloxone does not readily penetrate the blood-brain barrier, we conclude that the opiate receptors at which naloxone exerts its anorectic action are located in the brain rather than in potential peripheral tissues such as gastrointestinal tract, pancreas or adrenal medulla. The threshold-elevating effect of naloxone only became marked after rats had engaged in one or two 5-sec bouts of feeding. The effect continued to increase following each subsequent bout of feeding. Naloxone therefore appears to inhibit feeding by interacting with post-ingestive factors.

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PMID: 6843782


Other references

Murlidhar, V.; Zeinali, M.; Grabauskiene, S.; Ghannad-Rezaie, M.; Wicha, M.S.; Simeone, D.M.; Ramnath, N.; Reddy, R.M.; Nagrath, S., 2015: A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells. Circulating tumor cells (CTCs) are believed to play an important role in metastasis, a process responsible for the majority of cancer-related deaths. But their rarity in the bloodstream makes microfluidic isolation complex and time-consuming. Addi...

Folkert, V.W.; Schlondorff, D., 1983: Relationship between prostaglandin synthesis and phospholipid turnover in rat glomeruli: effect of trifluoperazine, A23187, and mepacrine. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 11: 513-516

Lundmark, Anders Mattias, 2008: Crustal growth in the Upper Jotun Nappe, SW Norway, constrained from in situ LA-ICPMS zircon Hf data, and the formation and evolution of the western edge of the Baltic Shield. The high-grade metamorphic Upper Jotun Nappe constitutes a displaced part of lower continental crust in the Caledonian nappe stack in south-western Norway. A comparison of the tectonometamorphic and magmatic evolution of the nappe to that of the W...

Dirsch, V.M., 1970: Acridoidea of the Congo Orthoptera. Annls Mus. r. Afr. cent. (Ser. 8, 182: 1-605

Gana P., 1991: Lower Mesozoic bimodal magmatism, Cordillera de la Costa, Elqui and Limari provinces, Coquimbo, Chile. Congreso Geologico Chileno: Resumenes Presentados 6: 525-528

Bostrom H., 1984: Multiple forms of cytochrome p 450 in the biosynthesis of bile acids. Acta Pharmaceutica Suecica 21(5): 318

Ford, D.M.; Hellon, R.F.; Luff, R.H., 1973: Cholinergic pathways in the brain stem subserving thermoregulatory mechanisms in the cat. Journal of Physiology 231(1): 34p-35p

Olson, A.-Negrete; Kinder, G.; Hannsz, M.-Lou, 1997: Cooking lite south of the border. Contains dietary guidelines for healthy eating, including a food guide pyramid and heart health reference material. Also provides nutritionally analyzed, healthy traditional Mexican recipes.

I.S.C.meron-Clarke; S.B.davari, 1981: Correlation of rock mass classification parameters obtained from borecore and in-situ observations. The paper describes an investigation carried out to establish correlation trends between rock mass classification parameters derived from borecore and in-situ observations. The purpose of this study was to determine the reliability of classifying...

Olson L.W., 1980: Allomyces neomoniliformis gametogenesis the cystogenes life cycle. In A. neomoniliformis meiosis takes place during resting sporangium germination. Meiospores are characteristically binucleate and biflagellate. Variation in number of nuclei and flagella per meiospore from two was correlated with germination of th...