geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of naloxone and its quaternary analogue on fluid consumption in water-deprived rats


, : Effects of naloxone and its quaternary analogue on fluid consumption in water-deprived rats. Neuropharmacology 22(6): 797-800

The effects of subcutaneous administration of naloxone and its quaternary analogue on the consumption of water, saline and saccharin solution were investigated in the water-deprived rat. Quaternary naloxone (0.01-10 mg . kg-1), effective in blocking peripheral opiate receptors, had no effect on fluid intake. In contrast, naloxone (0.01-10 mg . kg-1), produced dose-dependent attenuation of intake for each of the three fluids, indicating a central location of the relevant opiate receptors. Access to saline induced additional drinking, compared with water intake, due to an extension of the initial avid consumption which follows the period of water-deprivation. This enhancement of drinking was blocked by naloxone, but not by its quaternary analogue. Interactions between naloxone and taste factors in drinking may, therefore, depend on blockade of central opiate receptors.

US$29.90

PMID: 6888671


Other references

Anderson, W.A., 1962: Experimental stimulation of breast development in the teen-age female. Journal of the Medical Society of New Jersey 59: 541-543

Rayz, V.L.; Lawton, M.T.; Martin, A.J.; Young, W.L.; Saloner, D., 2008: Numerical simulation of pre- and postsurgical flow in a giant basilar aneurysm. Computational modeling of the flow in cerebral aneurysms is an evolving technique that may play an important role in surgical planning. In this study, we simulated the flow in a giant basilar aneurysm before and after surgical takedown of one vert...

Anonymous, 2012: Recent change of the global monsoon precipitation 1979–28. The global monsoon (GM) is a defining feature of the annual variation of Earth s climate system. Quantifying and understanding the present-day monsoon precipitation change are crucial for prediction of its future and reflection of its past. Here w...

Ito, J.; Heazlewood, J.-L.M.llar, A.H.rvey, 2007: The plant mitochondrial proteome and the challenge of defining the posttranslational modifications responsible for signalling and stress effects on respiratory functions. The mitochondrion is the principle organelle in plant aerobic respiration, where the oxidation of organic acids to CO subscript 2(B and H subscript 2(BO, combined with the coupling of electron transfer to O subscript 2(B via the respiratory electr...

Kuang, E.; Wan, Q.; Li, X.; Xu, H.; Zou, T.; Qi, Y., 2006: ER stress triggers apoptosis induced by Nogo-B/ASY overexpression. Nogo-B/ASY has been characterized as a novel human apoptosis-inducing protein without any known apoptosis-related motifs. However, the validity of Nogo-B/ASY as a physiological apoptotic protein was recently questioned. In present research, we dem...

Vette, A.; Burke, J.; Norris, G.; Landis, M.; Batterman, S.; Breen, M.; Isakov, V.; Lewis, T.; Gilmour, M.Ian.; Kamal, A.; Hammond, D.; Vedantham, R.; Bereznicki, S.; Tian, N.; Croghan, C., 2013: The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS): study design and methods. The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS) was designed to examine the relationship between near-roadway exposures to air pollutants and respiratory outcomes in a cohort of asthmatic children who live close to major...

Goresky C.A.; Bach G.G.; Gordon E.R., 1981: Uptake of straight chain mono hydric alcohols by the liver. Microvascular Research 21(2): 244

Mariguddi, S.; Wassmer, E., 2011: Mechanical ventilation in children with severe neurological impairment. Developmental Medicine and Child Neurology 52(11): 1068-1069

Shoham, J.; Watson, F.; McGrath, M., 2010: Humanitarian disaster response. Lancet 375(9718): 891-891

Xue, Z.; Wang, S.; Lin, L.; Chen, L.; Liu, M.; Feng, L.; Jiang, L., 2012: A novel superhydrophilic and underwater superoleophobic hydrogel-coated mesh for oil/water separation. Advanced Materials 23(37): 4270-4273