+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of naloxone on carotid body chemoreception and ventilation in the cat

, : Effects of naloxone on carotid body chemoreception and ventilation in the cat. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 51(6): 1533-1538

The effects of intravenous injection of naloxone (0.4, an opiate antagonist, on the responses of carotid body chemoreceptor discharge and ventilation to steady-state levels of hypoxia and hypercapnia were investigated in 12 anesthesized cats. After naloxone, carotid chemoreceptor response to hypoxia (PaO2 60--30 Torr) was enhanced, a finding that suggested that the endogenous enkephalin-like peptide present in the carotid body inhibits carotid chemoreceptors. This reasoning is supported by the observation that close intra-arterial injection of met-enkephalin inhibits carotid chemoreceptors and that the effect is blocked by naloxone. After naloxone, ventilation was stimulated even in the absence of a significant stimulation of carotid chemoreceptors during hyperoxia, indicating that ventilation is normally suppressed by endogenous opiates in the central nervous system, an effect disinhibited by naloxone. Also, the ventilatory effect of the peripheral chemoreceptor input was augmented after naloxone.


PMID: 6798001

Other references

Link G.; Chambers S.E.; Thompson J.A.; Falk H., 1981: Size and physical organization of chloroplast dna from mustard sinapis alba. Intact chloroplast (cp) DNA from mustard cotyledons (S. alba L.) was found by EM to be a uniform population of circular molecules with a contour length corresponding to 158 kilobase (kb) pairs. This size was confirmed by restriction endonuclease a...

Chiu, Ht, 1977: Mass rearing of the oriental fruit fly in Taiwan. Taiwan agriculture quarterly: 13 (3) 114-120

Hayer, B., 1975: Nectar producing trees and the northeastern beekeeper. American bee journal: 115 (2) 64

Jacobs F., 1988: The Neogene basin of Aliveri-Kymi on Euboea, Greece. Zeitschrift der Deutschen Geologischen Gesellschaft: 1, Pages 229-236. 1988.

Perper, J.A., 1974: Medical experimentation on captive populations in the United States. Journal of Forensic Sciences 19(3): 557-560

Pinheiro, R.; Belo, I.; Mota, M., 2002: Oxidative stress response of Kluyveromyces marxianus to hydrogen peroxide, paraquat and pressure. The aim of this work was to study the oxidative stress response of Kluyveromyces marxianus to hydrogen peroxide (50 mM), paraquat (1 mM), an increase in air pressure (120 kPa, 600 kPa) and pure oxygen pressure (120-600 kPa) in a pressurized biorea...

Romeis, T.; Höltje, J.V., 1994: Specific interaction of penicillin-binding proteins 3 and 7/8 with soluble lytic transglycosylase in Escherichia coli. Soluble lytic transglycosylase 70 (Slt70), one of the better characterized murein hydrolases of Escherichia coli, was covalently bound to CNBr-activated Sepharose and used as a specific tool to screen for proteins showing an affinity for Slt70. Se...

Nielsen, S.W., 1952: Nogle bemaerkninger on Skaerhiberin, Anthus spinoletta littoralis Brehm. Flora og Fauna(3-5): 93-99

Wang, E.; Lenferink, A.; O'Connor-McCourt, M., 2007: Cancer systems biology: exploring cancer-associated genes on cellular networks. Genomic alterations lead to cancer complexity and form a major hurdle for comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe recent advances in studying cancer-associated genes from a system...

Lorin, D.; Kopf, N., 1980: Rupture of the mesocolon descendens and partial necrosis of the colon as a result of prolapse of the colon during dystocia in a mare. Owing to the abnormal position of the foal (flexion of both shoulders) labour, during which prolapse of the colon occurred, lasted for eight hours. The dead fetus was removed by partial embryotomy. Fifty hours later circulatory disturbance and inc...