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Effects of naloxone on hemodynamics, oxygen transport, and metabolic variables in canine endotoxin shock


, : Effects of naloxone on hemodynamics, oxygen transport, and metabolic variables in canine endotoxin shock. Circulatory Shock 10(2): 147-160

The effects of naloxone (2 mg/kg body weight) on hemodynamics, oxygen transport, and some metabolic variables were studied in mongrel dogs under general anesthesia and controlled ventilation. All 19 dogs received Escherichia coli endotoxin (1.5 mg/kg) and subsequently were randomized into three groups. The first group (N = 7) served as a control group in which at 90 min after endotoxin (t 90), NaCl (0.65%, 4 ml/kg) was infused during 30 min. In the second group (N = 7) naloxone (2 mg/kg) dissolved in the same amount of fluid was administered at t 90 in 30 min. In the third group (N = 5) naloxone (2 mg/kg) was injected as a bolus in 5 ml NaCl (0.65%) at t 90, which was followed by NaCl (0.65%, 4 ml/kg) infused in 30 min. Differences in the three groups after intervention were tested statistically. After naloxone, blood pressure, cardiac output, and left ventricular stroke work increased significantly. Although oxygen availability increased, oxygen consumption and serum lactate did not change when compared with the control group. As to all other measured and calculated variables, no systematic differences were found in the three groups. In six dogs, plasma beta-endorphins were measured and were shown to rise substantially after induction of endotoxin shock. As to the hemodynamic changes, our observations confirm data from the literature. Naloxone apparently improves hemodynamics in endotoxin shock, but at least in this study fails to influence oxygen consumption and serum lactate levels.

US$29.90

PMID: 6839424


Other references

Schorlemmer D.; Jordan T.H., 2008: The Collaboratory for the Study of Earthquake Predictability; progress report. Seismological Research Letters 79(2): 332

D.J.ng J.H.; Oud J.L., 1980: Location and behavior of constitutive hetero chromatin during meiotic prophase in beta vulgaris. Male meiotic prophase of diploid sugar beet (B. vularis L.) was studied with emphasis on location and behavior of the constitutive heterochromatin during the early prophase stages. The succession of the stages is determined by using anther length,...

Mitkov V., 1975: Changes in cerebral electrical activity and blood supply in chronic alcoholics after unrepeated consumption of alcohol. Electroencephalography & Clinical Neurophysiology: 673-674

Sundquist, J.; Bajekal, M.; Jarman, B.; Johansson, S.E., 1996: Underprivileged area score, ethnicity, social factors and general mortality in district health authorities in England and Wales. Objective: To analyse the relation of ethnicity, social deprivation (Underprivileged area, UPA-score), social class V, unemployment and overcrowding on age- and sex-standardized mortality ratio (SMR). Design: This ecological study used the SMR for...

Ouellet D.; Hermann D.J.; Dukes G.E.; Koruda M.J.; Bertch J.; Hak L.J., 1991: Evaluation of the effect of labetalol and quinidine on p450iid6. Pharmacotherapy 11(3): 288

Kashyap, A.; Anand, K.; Kashyap, S., 2004: Rabies and other lyssavirus diseases. The full scale of the global burden of human rabies is unknown, owing to inadequate surveillance of this fatal disease. However, the terror of hydrophobia, a cardinal symptom of rabies encephalitis, is suffered by tens of thousands of people each...

Bachman, E.S., 2006: Role of energy expenditure in regulation of energy homeostasis. This chapter provides an overview on the physiology of energy expenditure and metabolism in man, citing relevant factors that affect overall energy homeostasis (i.e., physical activity, thyroid hormones, sympathetic nervous system, brown and white...

Kolarik, J.; Wargocki, P., 2011: Can a photocatalytic air purifier be used to improve the perceived air quality indoors?. The effect of a photocatalytic air purifier on perceived air quality (PAQ) was examined in rooms polluted by typical sources of indoor pollution. The rooms were ventilated at three different outdoor air supply rates. The air quality was assessed b...

Provost, A. (Director), 1975: Chad. Central Africa Region of Veterinary and Zootechnical Research. Annual report of Farcha Laboratory, 1974. Some retrenchment of the work of the Farcha Laboratories through lack of funds and loss of staff is reported. In spite of this, vaccine production increased in 1974. Vaccines were produced against rinderpest, pleuropneumonia, rabies, anthrax, blac...

Xia, X.; Chen, X.; Liu, R.; Liu, H., 2011: Heavy metals in urban soils with various types of land use in Beijing, China. Heavy metal concentrations of Cd, Cr, Cu, Ni, Pb and Zn were investigated for 127 urban soil samples collected from business area (BA), classical garden (CG), culture and education area (CEA), public green space (PGS), residential area (RA) and ro...