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Effects of naloxone on prolactin, luteinizing hormone, and cortisol responses to surgical stress in humans

, : Effects of naloxone on prolactin, luteinizing hormone, and cortisol responses to surgical stress in humans. Journal of Clinical Endocrinology and Metabolism 55(2): 378-380

To evaluate the possible involvement of endogenous opioid peptides in the responses of PRL, LH, and cortisol to surgical stress, we have studied the effect of naloxone on these hormones in otherwise normal subjects of both sexes undergoing cholecystectomy for gallstones. In 24 subjects (12 males and 12 females), premedication consisted of atropine sulfate (0.007 mg/kg BW); general anesthesia (30 min later) was induced by thiopental (7 mg/kg) and maintained constant by 1% ethrane in a 70%:30% nitrous oxide-oxygen mixture. In 6 males and 6 females, naloxone (0.4 mg) was injected iv before anesthesia induction. After skin incision, a clear PRL release was observed in all subjects; this was more evident in females than in males. PRL release was significantly lower in naloxone-pretreated subjects. LH release was observed only in males and was significantly higher in naloxone-pretreated subjects. Cortisol release occurred in both sexes in a similar way and was not significantly different in naloxone-pretreated subjects. Cortisol release occurred in both sexes in a similar way and was not significantly different in naloxone-pretreated subjects. These results indicate that endogenous opioid peptides are involved in stress-induced PRL and LH release in humans.


PMID: 7085859

DOI: 10.1210/jcem-55-2-378

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Hu, Z.; Lutkenhaus, J., 1999: Topological regulation of cell division in Escherichia coli involves rapid pole to pole oscillation of the division inhibitor MinC under the control of MinD and MinE. Placement of the Z ring at midcell in Escherichia coli is assured by the action of the min system, which blocks usage of potential division sites that exist at the cell poles. This activity of min is achieved through the action of an inhibitor of...

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Buzina, R.; Keys, A., 1956: Blood coagulation after a fat meal. The influence of meals on the coagulability of blood was studied in experiments on 20 men with parallel non-fed controls. The whole blood clotting time in siliconized tubes was not altered by a low-fat meal or by continued absence of a meal but it...

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Sanchez J.David, 1984: Flood tidal delta deposits in the Upper Cretaceous Blackhawk Formation and Star Point Sandstone, Wasatch Plateau, Utah. Abstracts with Programs - Geological Society of America 16(6): 643

Penfield, S.; King, J., 2009: Towards a systems biology approach to understanding seed dormancy and germination. Seed germination is the first adaptive decision in the development of many land plants. Advances in genetics and molecular physiology have taught us much about the control of germination using the model plant Arabidopsis thaliana. Here we review t...

Kohnz, R.; Scheunemann, H., 1959: Prolonged respiratory paralysis after succinyl-bis-choline chloride. Munchener Medizinische Wochenschrift 101(21): 928-929