geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neonatal 6-hydroxydopamine treatment on cortical development in mice and rats as monitored by developmental changes of gangliosides


, : Effects of neonatal 6-hydroxydopamine treatment on cortical development in mice and rats as monitored by developmental changes of gangliosides. Developmental Neuroscience 5(5-6): 554-566

In a comparative study newborn rats and mice received subcutaneous (s.c.) injections of 6-hydroxydopamine (6-OHDA: 100 mg/kg) on postnatal days (p.d.) 1-3. In rats the treatment permanently reduced synaptosomal 3H-noradrenaline (3H-NA) uptake in the cortex to about 50-60% of control values. Conversely, cortical 3H-NA uptake was only temporarily reduced in treated mice during the first week and central noradrenergic neurons completely recovered during the second and third week. The different response of mice and rats to 6-OHDA is suggested to be due to earlier maturation of the noradrenergic system in mice, making it less vulnerable to neonatal injections of the neurotoxin. To determine whether the development of the cortex would be altered after degeneration of its noradrenergic innervation, developmental changes of cortical ganglioside content and composition of 6-OHDA-treated animals were compared to that of littermate controls. In 18-day-old rats, where reduction of 3H-NA uptake had persisted, ganglioside content was reduced by 16.5%, indicating growth impairment of neuronal membrane structures. Cortical gangliosides of younger rats and all the stages studied in mice were not affected by 6-OHDA treatment.

US$29.90

PMID: 6819119


Other references

England, L.; Rosemond, A., 2004: Small reductions in forest cover weaken terrestrial-aquatic linkages in headwater streams. 1. We assessed the impacts of deforestation on the energy base of headwater food webs in seven headwater streams in the Upper Chattahoochee basin, GA, U.S.A where percentage forest in catchments ranged from 82 to 96%. We measured terrestrial organ...

Ersmark, K.; Feierberg, I.; Bjelic, S.; Hamelink, E.; Hackett, F.; Blackman, M.J.; Hultén, J.; Samuelsson, B.; Aqvist, J.; Hallberg, A., 2003: Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. The hemoglobin-degrading aspartic proteases plasmepsin I (Plm I) and plasmepsin II (Plm II) of the malaria parasite Plasmodium falciparum have lately emerged as putative drug targets. A series of C<sub>2</sub>-symmetric compounds encom...

Saita, G.; Moreo, L., 1959: Thalassemia and occupational diseases. II. Thalassemia and chronic lead poisoning. La Medicina del Lavoro 50(1): 37-44

Farkas, V.; Gresik, M.; Kolarova, N.; Sulova, Z.; Sestak, S., 1990: Biochemical and physiological changes during photoinduced conidiation and derepression of cellulase synthesis in Trichoderma. This paper on T. reesei [T. longibrachiatum] enzymes was presented at a symposium (TRICEL 89) held at the Technical University of Vienna, 14-16 Sep. 1989.

Schulman, J.; Stricof, R.; Stevens, T.P.; Horgan, M.; Gase, K.; Holzman, I.R.; Koppel, R.I.; Nafday, S.; Gibbs, K.; Angert, R.; Simmonds, A.; Furdon, S.A.; Saiman, L., 2011: Statewide NICU central-line-associated bloodstream infection rates decline after bundles and checklists. In 2008, all 18 regional referral NICUs in New York state adopted central-line insertion and maintenance bundles and agreed to use checklists to monitor maintenance-bundle adherence and report checklist use. We sought to confirm whether adopting s...

Tamura T.; Nagata S.; Ishikura F.; Akaike M.; Yamabe T.; Tamai J.; Yamagishi M.; Ohmori F.; Miyatake K.; E.A., 1989: Percutaneous transvenous mitral commissurotomy immediate and follow up results. Japanese Circulation Journal 53(8): 938

Errington, Paul L., 1939: Reactions of muskrat populations to drought. Varying periods of drought from 1934 to 1938 provided exceptional opportunities to study muskrat (Ondatra zibethica) populations living under emergency conditions especially in central and northwestern Iowa. Although the animals showed considerabl...

Meniconi, R.L.; Komatsu, S.; Perdigao, F.; Boëlle, P-Yves.; Soubrane, O.; Scatton, O., 2015: Recurrent hepatocellular carcinoma: a Western strategy that emphasizes the impact of pathologic profile of the first resection. Hepatocellular carcinoma (HCC) often recurs after curative resection, and thus the optimal treatment strategy to treat recurrences remains uncertain. We analyzed the results of different options to treat recurrent HCC and emphasized the impact of...

Salzgeber, B., 1976: Study on the genesis of malformations of distal parts of limbs in the chick embryo (adactylia, hemimelia). Comptes rendus hebdomadaires des seances Serie D Sciences naturelles: 283 (10) 1241-1244

Dunn, K.H.; Devaux, I.; Stock, A.; Naeher, L.P., 2008: Application of end-exhaled breath monitoring to assess carbon monoxide exposures of wildland firefighters at prescribed burns. Exposure to the range of combustion products from wildland fires has been demonstrated to cause respiratory irritation and decreased lung function among firefighters. The measurement of carbon monoxide (CO) has been previously shown to be highly c...