+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neonatal and adult 6-hydroxydopamine treatment on random-interval behavior

, : Effects of neonatal and adult 6-hydroxydopamine treatment on random-interval behavior. Pharmacology, Biochemistry, and Behavior 12(2): 281-285

Rats were given intraventricular injections of 6-hydroxydopamine (6-HDA) or saline-ascorbate vehicle as neonates (3-days old) and as adults (49 and 51 days old). At 73 days of age, they were trained on a random interval 90-sec schedule of water reinforcement. The rats treated with 6-HDA as adults stabilized at response rates approximately twice those of vehicle-treated rats, while rats treated with 6-HDA as neonates showed response rates which were not significantly different from vehicle-treated rats; Both L-Dopa and apomorphine decreased response rates at all doses tested. There were no differences among the groups with respect to the effect of these drugs. Adult-treated rats showed greater response rate decreases following peripheral decarboxylase inhibition with Ro 4-4602. Catecholamine analyses revealed the rats treated with 6-HDA as neonates had greater depletions in the striatum and the remainder of telencephalon than adult-treated rats but an increase in brainstem norepinephrine. These findings suggest that age of treatment is an important determinant of the biochemical and behavioral effects of treatment with 6-HDA.


PMID: 7375490

Other references

Adamson, P.A.; Strecker, H.D., 1996: Transcutaneous lower blepharoplasty. Transcutaneous lower blepharoplasty as a standard procedure for cosmetic lower blepharoplasty is being replaced by transconjunctival blepharoplasty and laser resurfacing techniques. Nevertheless, there remain specific indications for the transcuta...

Awschalom M.; Rosenberg I.; Haken R.K.T., 1983: Scaling neutron absorbed dose distributions from 1 medium to another. Central axis depth dose (CADD) and off-axis absorbed dose ratio (OAR) measurements were made in water, muscle and whole skeletal bone tissue-equivalent (TE) solutions, mineral oil and glycerin with a clinical neutron therapy beam. Evidently, for a...

Cosmi, E.V.; L.T.rre, R.;, R.; Anceschi, M.M., 1996: Surfactant administration to the human fetus in utero: a new approach to prevention of neonatal respiratory distress syndrome (RDS). Supplementary surfactant (80 mg in 1 ml) was administered intra-amniotically in proximity of the fetal mouth to 4 preterm fetuses (28 to 32 wks) with immature amniotic fluid indexes and whose delivery was imminent. Administration was preceded by a...

Marín, M.C.; Villegas, P.; Bennett, J.D.; Seal, B.S., 1996: Virus characterization and sequence of the fusion protein gene cleavage site of recent Newcastle disease virus field isolates from the southeastern United States and Puerto Rico. Nine Newcastle disease virus (NDV) isolates obtained from Puerto Rico, Georgia, Alabama, Mississippi, and Texas were analyzed for in vivo pathogenicity, biological properties (hemagglutination of mammalian erythrocytes), and for sequence variation...

Matthews, D., 1989: Occupational health in a meat-processing plant. Occupational Health; A Journal for Occupational Health Nurses 41(5): 130-132

Brothers, N., 1974: Relations between strange brown hawks. Bulletin Tasmat. Club: 7-8

Sandhya, K.S.; Suresh, C.H., 2015: Designing metal hydride complexes for water splitting reactions: a molecular electrostatic potential approach. The hydridic character of octahedral metal hydride complexes of groups VI, VII and VIII has been systematically studied using molecular electrostatic potential (MESP) topography. The absolute minimum of MESP at the hydride ligand (Vmin) and the ME...

Lin, C-Hsien.; Lin, Y-Chieh.; Yu, M-Hsien.; Su, H-Young., 2015: Primary pure large cell neuroendocrine carcinoma of the ovary. Taiwanese Journal of Obstetrics & Gynecology 53(3): 413-416

Borgia, Gerald, 1995: Threat Reduction as a Cause of Differences in Bower Architecture, Bower Decoration and Male Display in Two Closely Related Bowerbirds Chlamydera nuchalis and C. maculata. Major structural differences in the bowers of different bowerbird species have long been recognised, but the evolutionary significance of these differences has never been determined. I compared the bowers and displays of two congeneric species, th...

Anonymous, 2008: ACCESS Healthcare Coalition makes inroads on Medicaid funding crisis. Gha Today 52(1): 1, 3-1, 3