geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neonatal anti-delta antibody treatment on the murine immune system. II. Functional capacity of a stable sIgM+sIa+sIgD- B cell population


, : Effects of neonatal anti-delta antibody treatment on the murine immune system. II. Functional capacity of a stable sIgM+sIa+sIgD- B cell population. Journal of Immunology 131(2): 601-605

Mice were injected from birth with rabbit anti-mouse IgD (RaM delta). Studies in the accompanying paper indicated that the B cells from these mice have a stable sIgM+sIa+sIgD- B cell population. In the studies presented herein the in vivo and in vitro antibody responses of these mice were examined as well as their responsiveness to various B cell mitogens. The results indicate that splenic B cells from RaM delta-suppressed mice differ from normal adult murine splenic B cells by failure to express increased sIa antigen after in vitro stimulation with soluble anti-mu antibodies and failure to proliferate in response to in vitro stimulation with either soluble or Sepharose-bound anti-mu antibody. Nevertheless, these mice generate relatively normal in vivo IgM and IgG antibody responses to TI-2 and to both high and low epitope density forms of TD antigens as well as secondary IgG antibody responses to a TD antigen. In addition, B cells from RaM delta-treated mice generate relatively normal primary in vitro IgM antibody responses to TI-1, TI-2, and TD antigens. These data suggest that sIgD- B cells can produce antibody responses to the majority of antigenic signals even though they appear to lack one or more differentiative pathways.

US$29.90

PMID: 6602841


Other references

Warmenbol; Peeters; Devreese, 1986: Effect of the polaron-induced nonparabolicity of the energy-momentum relation on the dynamics of transport electrons. Physical Review. B, Condensed Matter 33(8): 5590-5594

Unal, D.; Yeni, E.; Verit, A.; Karatas, O.Faruk., 2005: Prognostic factors effecting on recurrence of urinary stone disease: a multivariate analysis of everyday patient parameters. Since comprehensive urometabolic analyses are currently more preferred for the patients with recurrent stones and with high risk of stone recurrence, we have tried to determine simple patient data increasing stone recurrence to limit sophisticated...

Madlensky, L.; Berk, T.C.; Bapat, B.V.; McLeod, R.S.; Couture, J.; Baron, D.; Hiruki, T.; Redston, M.; Cohen, Z.; Gallinger, S., 1995: A preventive registry for hereditary nonpolyposis colorectal cancer. Hereditary nonpolyposis colorectal cancer (HNPCC) is a genetic disorder characterized by a strong family history of colorectal and extracolonic cancers, usually at a young age. This article presents a new provincial service for families with HNPCC...

Balis, J.U.; Bumgarner, S.D.; Paciga, J.E.; Paterson, J.F.; Shelley, S.A., 1984: Synthesis of lung surfactant-associated glycoproteins by A549 cells: description of an in vitro model for human type II cell dysfunction. Immunocytochemical, ultrastructural, and biochemical approaches were used in a series of in vitro and in vivo experiments designed to identify characteristic changes reflecting differentiated type II cell function of A549 cells. Monolayers of A549...

Bateson, M.C., 1997: Validation of a rapid whole blood test for diagnosing Helicobacter pylori infection. A crucial reference just missed being cited. Bmj 314(7095): 1690-1690

Adelizzi, R.A., 1999: COX-1 and COX-2 in health and disease. NlmCategory="UNASSIGNED">Nearly 30 years ago, cyclooxygenase (COX) was identified as an enzyme that initiates the biotransformation of arachidonic acid to prostanoids. It is now known that COX exists as two distinct but similar isozym...

Silva, F.M. de A.; Penna, J.C.V.; Forti, L.C.; Santana, D.G. de, 2002: Occurrence of insect pests and their natural predators on glandless upland cotton genotypes. The effect of glandless cotton lines on the populations of cotton aphids (Aphis gossypii), thrips (Thrips tabaci), cotton leaf worms (Alabama argillacea), pink bollworms (Pectinophora gossypiella) and some predators was investigated in 1994-95 and...

Fujun Yao; Jianfeng He; Xiangjun Li; Hong Zou; Zhuobin Yuan, 2012: Studies of interaction of copper and zinc ions with Alzheimers A?1-16 using surface plasmon resonance spectrometer. Amyloid ? peptide plays a critical role in the pathogenesis of Alzheimer's disease(AD). Transition metals, such as Cu(II), Zn(II), and Fe(III) are found in A? plaques, and they have been shown to affect A? aggregation. Here we investigated th...

Ingerslev, J.; Wallevik, K., 1991: Clinical experience with Hemofil M in a hemophilia patient exhibiting inhibitors. Annals of Hematology 63(3): 152-154

Vahedi, K.; Boukobza, M.; Massin, P.; Gould, D.B.; Tournier-Lasserve, E.; Bousser, M-G., 2007: Clinical and brain MRI follow-up study of a family with COL4A1 mutation. Objective: To better delineate the clinical spectrum and the natural history of COL4A1 mutations, a newly defined genetic cause of small vessel disease including the brain and retina.Methods: Clinical and brain MRI follow-up study of a family with...