geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neonatal estrogenization on thymidine kinase activity and DNA content in the cerebellum of the rat


, : Effects of neonatal estrogenization on thymidine kinase activity and DNA content in the cerebellum of the rat. Developmental Neuroscience 3(4-6): 209-216

Cerebellar thymidine kinase activity and DNA content were determined following the administration of 17 beta-estradiol benzoate (EB) to neonatal rats during the sexually critical period of brain development. Male and female littermates were injected s.c. 24 and 72 h after birth with either 500 microgram EB or vehicle. At 3, 4, 6, 7, 8, 10, 12 and 15 days of age cerebellar thymidine kinase activity and DNA content were measured. A sexual dimorphism in thymidine kinase activity occurred in control rats between 6 and 15 days of age, i.e., enzyme activity was significantly higher in the cerebellum of the female rats. Thymidine kinase activity in both male and female EB-treated rats was (1) significantly greater than that of their littermate controls at 3 and 4 days of age, (2) the same as that for their controls at 6 days of age, (3) significantly lower than control levels between 7 and 12 days of age and, (4) the same as their controls by day 15. Alterations in cerebellar DNA content were similar to those described for the enzyme. These data demonstrate the occurrence of age-dependent estrogen-induced relationship(s) between thymidine kinase activity and DNA synthesis in the cerebellum of the rat during early postnatal development.

US$29.90

PMID: 7460793


Other references

Romero Rangel, T.; Stavrou, P.; Cotter, J.M.; Rosenthal, P.; Christen, W.; Foster, C.S., 1999: Gas permeable scleral contact lens therapy in ocular surface disease. IOVS 40(4): S909, March 15

Tinambunan, D., 1975: Forest road construction in Kalimantan. Reports a cost study at four forest concessions, including one already described [see FA 36, 3524], and compares the methods used at each stage (clearing, grading, compacting and surfacing). Total costs per km ranged from 1.5 to 3.1 million rupiah...

Kosinska, W.; Guttenplan, J.B., 1998: Mutagenesis by oral carcinogens in lacZ mouse oral tissue. Proceedings of the American Association for Cancer Research Annual Meeting 39: 184, March

Phelan, J.P., 1991: Critical care obstetrics: management of the fetus. Whenever a critically ill gravida presents for care, consideration should be given to consulting an obstetrician or a maternal-fetal medicine specialist. The technological advances of the past two decades permit these critical care obstetrical spe...

Gao, Q.-Feng; Mak, K.-Kei; Cheung, S.-Gin, 2002: The physiological ecology of black-ribbed mussels, Septifer virgatus (Wiegmann) (Bivalvia: Mytilidae) on a sub-tropical wave-exposed shore in Hong Kong. Oxygen consumption and ammonium excretion by Septifer virgatus were measured in situ on an exposed rocky shore monthly from January to December 1999. Condition index and reproductive cycle were determined simultaneously. Spawning was diphasic, the...

Barber, M.; Siskowski, C., 2008: Youth caregivers: unrecognized providers of care. Pediatrics 121(4): 873-874

Stroop, W.G.; Banks, M.C.reene; Qavi, H.; Chodosh, J.; Brown, S.M.ira, 1994: A thymidine kinase deficient HSV-2 strain causes acute keratitis and establishes trigeminal ganglionic latency, but poorly reactivates in vivo. The incidence of herpetic keratitis following intranasal or direct ocular infection with thymidine kinase-negative (TK-) strains of herpes simplex virus (HSV)-2 has not been well studied, and the role of the TK gene in the establishment of latency...

Kotha, S.P.; DePaula, C.Alex.; Mann, A.B.; Guzelsu, N., 2007: High frequency ultrasound prediction of mechanical properties of cortical bone with varying amount of mineral content. In this study, we evaluate if high frequency ultrasound impedance measurements can predict the mechanical properties of bones where the amount of bone mineral is varied. The motivation stems from the potential utility of ultrasound as a noninvasiv...

Z.X.ao; André R.L.plante; James A.F.nch, 2009: Quantifying the content of gravity recoverable platinum group minerals in ore samples. Minerals Engineering 22(3): 304-310

Baarsma E.A., 1979: Surgical treatment of the infected preauricular sinus. Preauricular sinus is a frequently occurring congenital abnormality (circa 0.25% in the white race), but usually gives no symptoms. In certain cases symptoms can arise as recurring purulent secretion or a preauricular abscess. If the disease is re...