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Effects of neonatal sympathetic denervation on amylase secretion in the adult rat parotid gland: difference in beta 1- and beta 2-adrenoceptor response

, : Effects of neonatal sympathetic denervation on amylase secretion in the adult rat parotid gland: difference in beta 1- and beta 2-adrenoceptor response. European Journal of Pharmacology 78(2): 195-200

Changes in amylase secretion and cyclic AMP accumulation in response to various secretagogues were studied in parotid glands of adult rats subjected to neonatal sympathetic denervation by unilateral excision of the superior cervical ganglion. Denervation decreased the gland content of amylase and both basal and the stimulated levels of cyclic AMP were elevated. The secretory cells of neonatally denervated glands exhibited enhanced maximal enzyme discharge in response to beta-adrenoceptor agonists. However, the selective beta 1-agonist, prenalterol was not effective in this respect whereas an enhanced maximal secretory response to the beta 2-selective agonist, terbutaline, was particularly prominent. DBcAMP was also more efficient in inducing amylase release from the denervated gland. The result of the present study demonstrate that the usual dominance of the beta 1-adrenoceptor subtype in eliciting amylase release is lost, implying that the differentiation of the beta-adrenoceptor into its subtypes is altered by neonatal sympathetic denervation.


PMID: 6176458

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Gupta, D.; Potthoff, S.; Blowers, D.; Corlett, J., 2006: Performance metrics for advanced access. Advanced access is an outpatient scheduling technique that aims to provide sameday appointment access. It is designed to reduce the time patients must wait for a scheduled appointment and to improve continuity of care by matching daily appointment...

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Chabros, E.; Charzewska, J.; Chotkowska, E., 1983: Correlations of lipid content of the body, relative body weight and hemoglobin level. Przeglad Lekarski 40(3): 309-314

Wang, Y.; Freund, D.M.; Magdaong, N.M.; Urban, V.S.; Frank, H.A.; Hegeman, A.D.; Tang, J.Kuo-Hsiang., 2015: Impact of esterified bacteriochlorophylls on the biogenesis of chlorosomes in Chloroflexus aurantiacus. A chlorosome is an antenna complex located on the cytoplasmic side of the inner membrane in green photosynthetic bacteria that contains tens of thousands of self-assembled bacteriochlorophylls (BChls). Green bacteria are known to incorporate vario...

Byzova Z.M., 1971: Geographic elements of the micro flora indigenous to the chu iliyskiye mountains. Botanicheskie Materialy Gerbariya Instituta Botaniki Akademii Nauk Kazakhskoi SSR (7): 80-87

Neubauer, B.A.; Hahn, A., 2016: Syndromes at risk of status epilepticus in children: genetic and pathophysiological issues. Status epilepticus (SE) is a medical emergency with increased risk of morbidity and mortality in all age groups. Recent research has identified a variety of new genes implicated in disorders with severe epilepsies as a prominent feature. Autoimmun...

Guy, A.; Molko, D.; Téoule, R., 1989: Synthesis of DNA fragments bearing 7,8-dihydro-8-oxo-adenine: a gamma radiation product. In order to investigate the mutagenic effects and the repair of DNA lesions induced by gamma rays, 7,8-dihydro-8-oxo-adenine was introduced in DNA fragments using cyanoethyl phosphoroamidite method. The modified oligonucleotides were purified by H...

O.R.illy Brian M.; Hauser Franz; Jacob A.W.B.ian; Shannon Pat M., 1996: The lithosphere below the Rockall Trough; wide-angle seismic evidence for extensive serpentinisation. The longer-range data from wide-angle seismic reflection experiments along an axial and transverse profile determined the seismic properties of the shallow mantle lithosphere beneath the Rockall Trough in the North Atlantic. Two subcrustal P- and...

Piermont, J.M.; Fagegaltier, D.; Levy, R.; Dorra, M., 1977: Hypokalemic tetraplegia as a manifestation of hyperthyroidism. La Nouvelle Presse Medicale 6(23): 2075-2076

Ternova, T.I., 1976: Inderal in the treatment of ectopic cardiac arrhythmias in children. Pediatriia: 55-58