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Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures

, : Effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures. Journal of Comparative and Physiological Psychology 95(3): 418-424

Seyfried, Glasser, and Yu recently reported that the DBA/2J mouse genotype, which is innately susceptible to audiogenic seizures, has high neonatal levels of thyroxine (T4) and that neonatal injections of T4 induce susceptibility in the C57BL/6J mouse. In the C57BL/6J mouse, neonatal T4 injections produced a temporary peripheral auditory dysfunction which appeared to be conductive in nature. A cochlear dysfunction was also seen in the DBA/2J mouse and in the acoustically primed C57BL/6J mouse. Since a peripheral auditory threshold elevation in these latter groups of mice appears to be causally related to their susceptibility to audiogenic seizures, it is likely that at least a portion of the susceptibility that Seyfried et al. reported was due to the effects of T4 on the ear.


PMID: 7251951

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