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Effects of nephrectomy on the pharmacokinetics of various cloned human interferons in the rat

, : Effects of nephrectomy on the pharmacokinetics of various cloned human interferons in the rat. Journal of Pharmacology and Experimental Therapeutics 227(1): 9-15

The pharmacokinetics of two human leukocyte interferon (IFN) subtypes (IFN-alpha A and IFN-alpha D) and two molecular hybrids [IFN-alpha AD(Bgl) and IFN-alpha AD(Pvu)] was studied in rats receiving single i.v. injections, 5.0 X 10(6) I.U./kg, of these materials. All four preparations were highly purified and resulted in plasma decay curves with similar elimination half-lives of 95.3 +/- 13.5 min. The four IFN-alpha subtypes investigated showed differences when their clearances are compared, suggesting that the 13 residue differences between amino acids 92 and 165 affect the clearance. The fact that only IFN-alpha D has an apparent volume of distribution (Vd beta) of 12.9 +/- 3.4 liters/kg whereas the other three IFN-alpha subtypes have Vd beta of 5.7 +/- 1.0 liters/kg suggests that the amino acid differences between residues 1 and 61 affect the Vd beta. Only in the case of IFN-alpha D did functional nephrectomy significantly (P = .02) increase the apparent volume of distribution at steady state. Functional nephrectomy before i.v. injection resulted in a 4-fold decrease in IFN-alpha AD(Bgl) and IFN-alpha AD(Pvu) clearance, an 8-fold decrease in IFN-alpha A clearance and a 10-fold decrease in IFN-alpha D clearance. The elimination half-life of each interferon was unchanged after nephrectomy. Intramuscular administration of the IFN-alpha subtypes in rats produced low plasma concentrations. IFN-alpha D peaks at 39 +/- 10 I.U./ml of plasma, whereas IFN-alpha A reaches 201 +/- 53 I.U./ml, IFN-alpha AD(Bgl) reaches 396 +/- 47 I.U./ml and IFN-alpha AD(Pvu) results in a maximum plasma concentration of 747 +/- 66 I.U./ml.


PMID: 6620174

Other references

Mezhzherin, SV., 1995: The discovery of a species of shrew new to the fauna of Ukraine (Insectivora, Soricidae).. Vestnik Zoologii. sentyabr'-dekabr'; 5-6: 17

Hartwig, G.W., 1981: Smallpox in the Sudan. International Journal of African Historical Studies 14(1): 5-33

Valdueza, J.M.; Schmierer, K.; Mehraein, S.; Einhäupl, K.M., 1996: Assessment of normal flow velocity in basal cerebral veins. A transcranial doppler ultrasound study. Background and Purpose: Transcranial Doppler ultrasound has not yet been applied systematically to the analysis of the venous system and cerebrovenous disorders. Assessment of the intracranial venous system, however, would contribute to the unders...

Fortunati, D.; Reppe, S.; Fjeldheim, A-Karine.; Nielsen, M.; Gautvik, V.T.; Gautvik, K.M., 2011: Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone. Periostin is a 90 kDa secreted protein, originally identified in murine osteoblast-like cells, with a distribution restricted to collagen-rich tissues and certain tumors. In this paper, we first analyzed the expression of periostin mRNA and protei...

Kim, T.; Jeon, H.Mi.; Le, H.Thi.; Kim, T.Woo.; Kang, C.; Kim, J.Seung., 2015: A biotin-guided fluorescent-peptide drug delivery system for cancer treatment. Herein, we present a fluorescent-peptide drug delivery system composed of biotin-naphthalimide-HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor...

Swartz, T.E.; Szundi, I.; Bogomolni, R.A., 2000: The sensory rhodopsin-I/HTR1 molecular complex Stoichiometry and chromophore protein interactions. Biophysical Journal. 78(1 Part 2): 477a,.

Nichols S.J.; Kollar B., 1992: Reproductive cycle of zebra mussels dreissena polymorpha in western lake erie at monroe michigan. Journal of Shellfish Research 11(1): 235

Anonymous, 1970: Editorial. Money for education. Journal of the Canadian Dental Association 36(9): 311-311

Shushkovskiĭ, B.Z., 1967: Damping the noise of 6500-12-1 blowers (smoke exhaust fans). Gigiena Truda i Professional'nye Zabolevaniia 11(9): 47-48

Cheung, N.K.V.; Dorf, M.E.; Benacerraf, B., 1977: Genetic control of the primary humoral response to Glu56Lys35Phe9. The primary humoral responses of mice to the linear random terpolymer L-Glu56-L-Lys35-L-Phe9 (GL phi ) were studied. The data are consistent with the hypothesis that 2 complementing Ir genes are required for the primary IgM response to GL phi , in...