+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neuroleptics on phencyclidine (PCP)-induced locomotor stimulation in mice

, : Effects of neuroleptics on phencyclidine (PCP)-induced locomotor stimulation in mice. Neuropharmacology 23(2a): 175-181

A variety of neuroleptics were compared for their ability to block phencyclidine (PCP)-induced behavioral stimulation in mice. Methiothepin, fluphenazine, trifluoperazine, and chlorpromazine were highly effective in blocking phencyclidine-induced stimulation at doses that did not decrease spontaneous behavioral activity. Clozapine, thioridazine and haloperidol were moderately effective, while sulpiride, molindone, and pimozide were completely ineffective. The effectiveness of the drugs was found to be correlated with their ability to block tryptamine-induced seizures and with several other measures of antidopaminergic and antiserotonergic potency. it is concluded that a combination of antidopaminergic and antiserotonergic activity is important for blocking the stimulating effects of phencyclidine.


PMID: 6144071

Other references

Ekman, P.; O'Sullivan, M., 1988: The role of context in interpreting facial expression: comment on Russell and Fehr (1987). In their article, "Relativity in the Perception of Emotion in Facial Expressions," Russell and Fehr (1987) argued that context is the principal determinant in interpreting facial expressions of emotion. They questioned the biological bas...

Ahmad, T.; Munir, A.; Bhatti, S.Haider.; Aftab, M.; Raza, M.Ali., 2017: Survival analysis of heart failure patients: A case study. This study was focused on survival analysis of heart failure patients who were admitted to Institute of Cardiology and Allied hospital Faisalabad-Pakistan during April-December (2015). All the patients were aged 40 years or above, having left vent...

Josset J.L.; Beauvivre S.; Cerroni P.; D.S.nctis M.C.; Pinet P.; Chevrel S.; Langevin Yves; Barucci M.A.; Plancke P.; Koschny D.; Almeida M.; Sodnik Z.; Mancuso S.; Hofmann B.A.; Muinonen K.; Shevchenko V.; Shkuratov Yu; Ehrenfreund P.; Foing B.H., 2006: SMART-1/ AMIE camera system. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference 37: (unpaginated

Iwamura N.; Bishop V.S., 1979: Neural pathways of cardiac afferents activated during brief coronary occlusion in cats. Federation Proceedings 38(3 PART 1): 1320

Stockman, R., 1940: The Treatment of Sciatica, Brachialgia, and Occipital Headache. Annals of the Rheumatic Diseases 2(2): 77-82

Ono, Y.; Futamura, R.; Hattori, Y.; Sakai, T.; Kaneko, K., 2017: Adsorption-desorption mediated separation of low concentrated D 2 O from water with hydrophobic activated carbon fiber. The adsorption and desorption of D<sub>2</sub>O on hydrophobic activated carbon fiber (ACF) occurs at a smaller pressure than the adsorption and desorption of H<sub>2</sub>O. The behavior of the critical desorption pressure...

Boström, P.A.; Diemer, H.; Freitag, M.; Juhlin, P.; Lilja, B.; Erhardt, L., 1992: Myocardial reperfusion in thrombolysis A 99Tcm-Sestamibi SPECT study in patients with acute myocardial infarction. This study presents the outcome of myocardial scintigraphy performed before and after thrombolytic treatment in 16 patients with acute myocardial infarction using 99Tcm-Sestamibi (Cardiolite, Du Pont Scandinavia AB, Kista, Sweden). The patients we...

Pfeifer, G.Kuhn.; Corleta, O.; Gus, P., 2009: Evaluation of computed tomographic colonography for detection of colorectal polyps. Computed tomographic colonography has been proposed for detection of colorectal polyps instead of colonoscopy in colorectal cancer screening programs. To evaluate the performance of computed tomographic colonography in the detection of colorectal...

Kim, JM.; Yi, SK.; Hue, SB.; Kim, DY.; Lee, JH.; Lee, JH.; Huh, HT., 1981: Marine ecological study on three brackish lakes along the east coast of Korea. BULLETIN OF KOREA OCEAN RESEARCH and DEVELOPMENT INSTITUTE: 31: 29-37

Leys, A.R., 2000: Broom (Cytisus scoparius (L.) Link) population management strategies. A session was conducted during the broom management workshop aimed at developing 'best bet' strategies for broom in a range of typical situations where broom needs to be managed: a national park; catchment management; an infested townshi...