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Effects of neuroleptics on platelet monoamine oxidase activity

, : Effects of neuroleptics on platelet monoamine oxidase activity. Biological Psychiatry 17(8): 885-895

Platelet MAO activity in schizophrenics was significantly decreased, by about 15%, after 3 weeks of treatment with haloperidol. Treatment with thioridazine or butaperazine also tended to decrease platelet MAO activity. The neuroleptic-induced decrease began to appear within a few days of treatment and did not show tolerance over 1-2 months of treatment with haloperidol. Platelet MAO activity of schizophrenic patients measured during drug-free base-line was not significantly different from that of normal controls, but MAO activity of schizophrenics was significantly lower than normals after 3 weeks of treatment with neuroleptics. The extent of decrease in platelet MAO activity correlated negatively with base-line prolactin and its increase after 24 hr. With PEA as substrate, the decrease in activity correlated positively with steady state plasma haloperidol.


PMID: 6126230

Other references

Prayer Galletti, F.; Bernardini, U.D.; Grandini, R., 1970: Mucous secretory activity of the salivary gland of the rat studied by histochemical methods in relation to developmental phases. II. Postnatal period. Rivista Italiana di Stomatologia 25(11): 1037-1041

Frey, J.D.; Alperovich, M.; Chun Kim, J.; Saadeh, P.B.; Hazen, A.; Levine, J.P.; Ahn, C.Y.; Allen, R.; Choi, M.; Schnabel, F.R.; Karp, N.S.; Guth, A.A., 2015: Oncologic Outcomes After Nipple-Sparing Mastectomy: A Single-Institutional Experience. Plastic and Reconstructive Surgery 136(4 Suppl): 87-88

Mayer H., 1988: On padda fuscata. Gefiederte Welt 112(6): 176

Nazimabashir; Manoharan, V.; Miltonprabu, S., 2016: Cadmium induced cardiac oxidative stress in rats and its attenuation by GSP through the activation of Nrf2 signaling pathway. Cadmium (Cd) is one of the toxic heavy metals in the environment, which induces oxidative stress, dyslipidemia and membrane disturbances in heart. The present study was designed to evaluate the role of grape seed proanthocyanidins (GSP) against Cd...

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Sala, M.; Janer, G.; Font, C.; Garau, I.; Solé, M.D.; Corbella, T.; Partanen, T.; Kogevinas, M., 2002: Employees attitudes to workplace health promotion programs for cancer prevention. [corrected] We describe a method for feasibility assessment of workplace health promotion (WHP) programs as a necessary prerequisite of any WHP program. A total of 167 employees from five workplace communities participated in the study. A question...

Hoiland, K., 1978: Finds of melanospora tulasnei new record a parasitical pyrenomycete in norway. The fungicolous pyrenomycete M. tulasnei Udgawa and Chain is reported for the 1st time from Norway. The perithecia were found among asci and paraphyses in the hymenium of the discomycete Geopora arenicola (Lev.) Kers collected in the sand-dune are...

Wuhl, E.; Witte, K.; Soergel, M.; Mehls, O.; Schaefer, F.; The German Working Group O.P.diatric Hypertension, 2001: Novel reference values for the calculation of SD scores in pediatric ambulatory blood pressure monitoring. Journal of the American Society of Nephrology 12(Program and Abstract Issue): 495A, September

Smalley, R.; Gams, R., 1983: Phase II study of mitoxantrone in patients with metastatic breast carcinoma: a Southeastern Cancer Study Group project. Cancer Treatment Reports 67(11): 1039-1040

Anonymous, 1968: Annual report of studies in animal nutrition and allied sciences. Vol. 24. The report includes the following studies: (1) synchronisation of mating in rats; (2) body composition of calves; and (3) of pregnant ewes; (4) intensive sheep production using Dorset Horn mated to Finnish Landrace and their progeny mated to rams...