+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neurotensin and neurotensin analogues on the migrating myoelectrical complexes in the small intestine of rats

, : Effects of neurotensin and neurotensin analogues on the migrating myoelectrical complexes in the small intestine of rats. Acta Physiologica Scandinavica 112(2): 203-208

The purpose of the present experiments was to study the effect of neurotensin and neurotensin analogues on the migrating myoelectrical complexes in the small intestine of rats. Four bipolar electrodes were implanted into the muscular wall of the small intestine. The electrodes were placed 5, 15, 25 and 35 cm distal to the pylorus. 7-10 days after the operation the animals were fasted for 48 h with free access to water. Some experiments were performed on conscious rats and in others the rats were anesthetized with pentobarbital, 30 mg/kg. I.v. infusion of either neurotensin (NT) or (Gln4)-neurotensin at doses of 1.8, 3.6 and 7.1 pmol X kg-1 X min-1 abolished the migrating myoelectric complexes, which were replaced by increased spiking activity along the whole length of the small intestine from which activity was recorded. The changes in myoelectrical activity were observed within 2-4 min after commencement of the infusion. The activity returned to control levels within 5-15 min after the end of the infusion period. The neurotensin sequences NT 9-13, NT 8-13, NT 4 -13, NT 1-9 and (Gln4)-NT 1-11 did not induce any changes in the electrical activity in the small intestine. The effects of NT and (Gln4)-neurotensin on the myoelectrical activity in the small intestine were indistinguishable. The changes induced by NT or (Gln4)-NT resemble those found after the ingestion of food. The present data indicate that the intact NT sequence, rather than smaller NT fragments, is necessary to induce changes in myoelectrical activity in the small intestine.


PMID: 7315414

DOI: 10.1111/j.1748-1716.1981.tb06805.x

Other references

Leemann, R.A., 1964: The Surgical Treatment Of Bronchial Asthma By Excision Of The Glomus Caroticum. Therapeutische Umschau. Revue Therapeutique 21: 148-152

Salim, R.; A.S.bu, M.M.; Atallah, A., 1993: Effects of root and foliar treatments with lead, cadmium, and copper on the uptake distribution and growth of radish plants. The effects of treatment of radish plants with cadmium, lead, and copper were studied. Both root treatment and foliar treatment were used. All three elements were found to inhibit the growth of radish plants. Cadmium and lead were greater growth i...

Benioff Hugo, 1935: A linear-strain seismograph. Bulletin of the Seismological Society of America: , Pages 283-309. 1935.

Shirakashi T.; Yamaguchi S.; Kakii K.; Kuriyama M., 1990: Toxic effects of mercuric ion on the growth of chlorella sp in the presence of bromine ion and thiocyanate ion. The toxin effects of mercuric ion on the growth of Chlorella sp. were studied in 0.5% glycine medium containing Br- or SCN-. In the present of Br-, turbidimetric measurement showed that the cells had a lag before growth even at a concentration of...

Pancholi, P.; Healy, M.; Bittner, T.; Webb, R.; Wu, F.; Aiello, A.; Larson, E.; Latta, P.Della., 2005: Molecular characterization of hand flora and environmental isolates in a community setting. We analyzed 69 bacterial isolates, comprising seven species of gram-negative bacterial rods and three species of coagulase-negative staphylococci, recovered from both the hands of caretakers and their environment in households sampled in upper Man...

Denness B., 1990: Determining natural and man made climate change historical review and implications for the 1900s and beyond. Paepe, R , R W Fairbridge And S Jelgersma Nato Asi (Advanced Science Institute) Series Series C Mathematical And Physical Sciences, Vol 325 Greenhouse Effect, Sea Level And Drought; Workshop on Geohydrological Management Of Sea Level And Mitigation Of Drought, Fuerteventura, Canary Islands, Spain, March 1-7, 1989 Xix+718p Kluwer Academic Publishers: Dordrecht, Netherlands; Boston, Massachusetts, Usa Illus Maps 41-74

Manik, R.S.; Singla, S.K.; Palta, P.; Madan, M.L., 1998: Ovarian follicular dynamics monitored by real-time ultrasonography during oestrous cycle in buffalo (Bubalus bubalis). During the winter, the ovaries of 6 cycling buffaloes (6-7 years of age, 450-550 kg body weight), maintained at the Indian National Dairy Research Institute, were examined daily over 1 compete oestrous cycle (ovulation = day 0) using transrectal u...

Snyder, C.D., 1925: Egg-volume and fertilization membrane. Biological Bulletin Wood's Hole, 49: 54-60

Claesson, L.; Lindén, T.; Skoog, I.; Blomstrand, C., 2004: Cognitive impairment after stroke - impact on activities of daily living and costs of care for elderly people. The Göteborg 70+ Stroke Study. The economic burden of stroke is substantial and is likely to increase with an increasing number of elderly individuals in the population. There is thus a need for information on the use of health care resources and costs among these elderly strok...

Himpsel, 1991: Exchange splitting of epitaxial fcc Fe/Cu(100) versus bcc Fe/Ag(100). Physical Review Letters 67(17): 2363-2366