+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neurotensin on the transit of gastrointestinal contents in the rat

, : Effects of neurotensin on the transit of gastrointestinal contents in the rat. Acta Physiologica Scandinavica 115(2): 239-243

In this study the influence of neurotensin on gastric emptying, transit of gastrointestinal contents and ileo-cecal emptying was studied in the conscious rat. A bolus of radioactive marker was deposited in the gastrointestinal lumen and was monitored at different time intervals during its passage along the bowel. Gastric emptying was inhibited in a dose-dependent manner by i.v. infusion of 6 and 12 (p less than 0.01) pmol x kg-1 x min-1 of neurotensin. The transit of the gastrointestinal contents was retarded by 3 (p less than 0.001) and 6 (p less than 0.001) pmol x kg-1 x min-1. In addition, at 12 pmol x kg-1 x min-1 the distribution of the radioactivity was spread out and the radioactive front migrated farther. Infusion of 6 pmol x kg-1 x min-1 of neurotensin also produced spreading of the radioactivity in the intestine with proximal pooling and rapid migration of the front of the radioactive bolus (p less than 0.001). Ileo-cecal emptying was inhibited by neurotensin at 6 pmol x kg-1 x min-1, with pooling of the radioactivity proximal to the ileo-cecal valve (p less than 0.001). These data indicate that neurotensin prolongs the transit time of the chyme in the stomach and small intestine. Thus, neurotensin may facilitate thorough digestion of the chyme in the small intestine and enhance the absorption of nutrients.


PMID: 7136817

DOI: 10.1111/j.1748-1716.1982.tb07071.x

Other references

Tarawak, E.; Iliynskaya, O.; Loktionova, S.; Kalinina, N., 1998: Local interaction of human aortic polymorphous endothelium with blood leukocytes Role in atherogenesis. Atherosclerosis 136(SUPPL ): S58, March

Amzica, F.; Steriade, M., 1995: Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation. The intracortical synaptic linkages underlying the synchronization of a recently described slow (< 1 Hz) oscillation (Steriade et al., 1993b,c) were investigated in anesthetized cats by means of multisite extra- and intracellular recordings, in...

Blundell, T.L.; Cutfield, J.F.; Dodson, G.G.; Dodson, E.; Hodgkin, D.C.; Mercola, D., 1971: The structure and biology of insulin. Biochemical Journal 125(3): 50p-51p

Chen, F.; Cole, P.; Bina, W.F., 2007: Time trend and geographic patterns of lung adenocarcinoma in the United States, 1973-2002. Objective: To find the major factor explaining the substantial increase in incidence of adenocarcinoma of the lung (ADL), we observed its temporal trend, distributions in geographic areas and populations, and compared them with the distributions o...

Monteil, G., 1966: Relations between homeopathy and orthodontics. Revue Francaise D'odonto-Stomatologie 13(2): 228-233

Austyn, J.M., 1993: The dendritic cell system and anti-tumour immunity. Dendritic cells (DC) are essential for the initiation of T- and T-dependent immune responses by virtue of their capacities to acquire, process and present antigens and to deliver activation signals to mature resting T cells. In contrast, antigen p...

Suda T.; Miyaura C.; Ishimi Y.; Takahashi N.; Udagawa N.; Akatsu T., 1990: The role of differentiation inducing factors difs in bone metabolism. Cohn, D V , F H Glorieux And T J Martin (Ed ) International Congress Series, 886 Calcium Regulation And Bone Metabolism: Basic And Clinical Aspects; Proceedings Of The 10th International Conference on Calcium Regulating Hormones And Bone Metabolism, Montreal, Quebec, Canada, September 9-14, 1989 Xxi+533p Elsevier Science Publishers B V : Amsterdam, Netherlands; (Dist in The Usa And Canada By Elsevier Science Publishing Co , Inc : New York, New York) Illus 270-279

Siegfried, Jean, 1961: Topography of the cortical projections of the vagus nerve in the cat. Electrophysiological responses to electric stimulation of the vagus nerve were recorded by a method permitting responses of small amplitude. Responses were obtained in two cortical areas; one (vagal area A) is situated between the end of the coron...

Lu, D.; Batistella, M.; Moran, E.; Mausel, P., 2004: Application of spectral mixture analysis to Amazonian land-use and land-cover classification. Abundant vegetation species and associated complex forest stand structures in moist tropical regions often create difficulties in accurately classifying land use and land cover (LULC) features. This paper examines the value of spectral mixture ana...

Kadam, A.N.; Dhabbe, R.S.; Kokate, M.R.; Gaikwad, Y.B.; Garadkar, K.M., 2015: Preparation of N doped TiO2 via microwave-assisted method and its photocatalytic activity for degradation of Malathion. We report herein, nitrogen doped TiO2 nanostructure synthesized by simple microwave assisted method, where ammonia was used as hydrolyzing agent. The synthesized nanomaterials were characterized by means of X-ray diffraction (XRD) which demonstrat...