geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neurotransmitter candidates on 45Ca uptake by cortical slices of rat brain: stimulatory effect of L-glutamic acid


, : Effects of neurotransmitter candidates on 45Ca uptake by cortical slices of rat brain: stimulatory effect of L-glutamic acid. Brain Research 248(2): 305-311

The effects of neurotransmitter candidates and the characteristics of the stimulatory effect of L-glutamic acid (L-Glu) on 45Ca uptake by rat brain slices were investigated. 45Ca uptake was significantly stimulated by acetylcholine, serotonin and especially L-Glu, but not by other neurotransmitter candidates. L-Glu caused dose-dependent stimulation of 45Ca uptake (L-Glu-stimulated 45Ca uptake), its effect being half-maximal at 1 microM. The related compounds D-glutamic acid, D,L-alpha-aminoadipic acid and N-methyl-D,L-glutamic acid (final conc. of 10 microM) also stimulated 45Ca uptake, but less than 10 microM L-Glu. D,L-alpha-Methylglutamic acid and L-glutamic acid diethylether (final conc. of 10 microM), which are specific inhibitors of L-Glu, inhibited L-Glu-stimulated 45Ca uptake. Mg,Ca-ATPase activity was hardly affected by a concentration of 10 microM L-Glu that caused maximal stimulation of 45Ca uptake. These findings suggest that L-Glu-stimulated 45Ca uptake by brain cortical slices is linked to L-Glu receptor.

US$29.90

PMID: 6128054


Other references

Bhattacharyya, G.; Pandya, S.M., 1996: Ecological assessment on agroecosystems of Saurashtra with special reference to weeds. Most of the weeds are found completing their life cycle simultaneously with the crop. In Kharif crops Echinochloa colonum. E. crusgalli and Cynodon dactylon, in wheat, Chenopodium album and C. murale exhibited higher SDR at all the locations. The...

Henderson, D.A., 1965: Newer Surveillance Methods In The Control Of Communicable Disease. Ii. Viral Hepatitis. Experience In The United States. Milbank Memorial Fund Quarterly 43: 404-411

Achab, S.; Diker, K.; Potier, P., 2001: A short route to functionalized imidazo carbazoles Synthesis of the first example of the imidazo beta-carboline ring system. A new synthetic route to functionalized imidazo(4,5-c)carbazoles (4) via intramolecular electrocyclization of indolo-1,3,5-hexatriene system (3a) is described. Thermally induced ring-closure of 2-ethylcarboxylate-(4-amino-5-imidazolyl)-3-indole (3...

Markwalder, H.; Fonio, A.C., 1969: In memoriam Anton Christian Fonio (1881-1968). Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie 105(1): 101-102

Gigov, A., 1956: The post-glacial history of Serbian forests.. Reviews literature, mainly Slav, on pollen-analysis studies for different species and areas in Serbia.

Harris, M., 2002: Perfect 10. Managing your own patient caseload. Nursing Times 96(34): 33-33

Böhm, M., 2016: Heart rate as emerging risk indicator in stroke - the beat goes on. European Journal of Neurology 23(12): 1698-1699

Chaudhuri Amarjyoti, 1988: Metamorphic recrystallisation, P-T regime and energy transformation in Chitradurga greenstone belt, Karnataka, India. Indian Minerals 42(3-4): 198-213

Nguyen, H.T.; Quandt, S.A.; Summers, P.; Morgan, T.M.; Chen, H.; Walker, F.O.; Howard, T.D.; Galván, L.; Arcury, T.A., 2016: Learning Ability as a Function of Practice: Does It Apply to Farmworkers?. Farmworkers experience significant work-related health risks including pesticide-associated cognitive impairment. Practice effect is a surrogate for learning ability. This study examined differences in cognitive function and learning capacity in L...

Oppenheim, C.; Mamou-Mani, T.; Sayegh, N.; de Blic, J.; Scheinmann, P.; Lallemand, D., 1994: Bronchopulmonary dysplasia: value of CT in identifying pulmonary sequelae. OBJECTIVE: Pulmonary dysfunction is common in children who survive bronchopulmonary dysplasia. Chest radiographs are not satisfactory for the identification of the sequelae of bronchopulmonary dysplasia because, although they often show abnormalit...