geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nicorandil, a new antianginal agent, and nifedipine on collateral blood flow in a chronic coronary occlusion model


, : Effects of nicorandil, a new antianginal agent, and nifedipine on collateral blood flow in a chronic coronary occlusion model. Journal of Pharmacology and Experimental Therapeutics 229(2): 359-363

The effects of nicorandil and nifedipine on collateral blood flow were compared in anesthetized dogs with a well-developed collateral circulation produced by Ameroid constriction (6-8 weeks) of the left anterior descending (LAD) coronary artery. The radioactive microsphere technique was used to determine myocardial perfusion in the normal left circumflex (LC) region and in the LAD region distal to the Ameroid constrictor. Low and high doses of nicorandil (25 and 50 micrograms/kg/min) or nifedipine (1 and 3 micrograms/kg/min) were infused i.v. to reduce mean arterial and left ventricular systolic pressure approximately 10 and 25 mm Hg, respectively. A low dose of nicorandil had no effect on myocardial perfusion whereas nifedipine increased subepicardial blood flow in both the LC and LAD regions. The high dose of nifedipine further increased both subepicardial and subendocardial perfusion to the LC region and subepicardial blood flow to the LAD region whereas nicorandil had no effect. When aortic blood pressure was returned to control by occluding a snare around the descending thoracic aorta during infusion of the high dose, nicorandil and nifedipine increased subepicardial and subendocardial blood flow to LAD and LC regions. Whereas nicorandil increased flow to both tissue layers equally, nifedipine increased subepicardial perfusion primarily. In summary, nifedipine increased collateral blood flow in a chronic coronary occlusion model despite the presence of systemic hypotension, whereas nicorandil only increased flow when aortic blood pressure was maintained. However, nicorandil increased myocardial blood flow equally across the left ventricular wall, whereas nifedipine primarily increased subepicardial blood flow.

US$29.90

PMID: 6232374


Other references

Molla, M.Rahaman.; Marcinko, T.; Prasad, P.; Deming, D.; Garman, S.C.; Thayumanavan, S., 2015: Unlocking a caged lysosomal protein from a polymeric nanogel with a pH trigger. A polymeric nanogel has been used to sequester and turn off a lysosomal protein, acid α-glucosidase (GAA). The nanogel contains a β-thiopropionate cross-linker, which endows the nanogel with pH-sensitivity. While encapsulation of the enzyme full...

Miyake, T.; Nakayama, T.; Naoi, Y.; Yamamoto, N.; Otani, Y.; Kim, S.J.; Shimazu, K.; Shimomura, A.; Maruyama, N.; Tamaki, Y.; Noguchi, S., 2012: GSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer. The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers...

Macleod F.A.; Guiot S.R.; Samson R., 1989: The ultrastructure of granules obtained from an anaerobic upflow bed filter reactor. Abstracts of the Annual Meeting of the American Society for Microbiology 89: 289

Abaturov, B.D., 1966: The effect of the burrowing activity of Talpa europaea on the cycle of substances in the forest biogeocoenosis. cf. F.A. 28 No. 64.] Tabulates and discusses the results of measurements of the volume and weight of soil brought to the surface from a depth of 10-40 cm., i.e. from the A2, A2B and B1 horizons, and of the quantities of mineral elements present in...

Picard M.Dane, 1985: Stratigraphic sequence, depositional environments, and sandstone types, western Uinta Mountains and Uinta Basin. Utah Geological Association Publication 12: 19-20

UmerRashid; FarooqAnwar; Moser,B.R.; Knothe,G., 2008: Moringa oleifera oil a possible source of biodiesel. Biodiesel is an alternative to petroleum-based conventional diesel fuel and is defined as the mono-alkyl esters of vegetable oils and animal fats. Biodiesel has been prepared from numerous vegetable oils, such as canola (rapeseed), cottonseed, pal...

McClain, D.E.; Benson, K.A.; Dalton, T.K.; Ejnik, J.; Emond, C.A.; Hodge, S.J.; Kalinich, J.F.; Landauer, M.A.; Miller, A.C.; Pellmar, T.C.; Stewart, M.D.; Villa, V.; Xu, J., 2001: Biological effects of embedded depleted uranium (DU): summary of Armed Forces Radiobiology Research Institute research. The Persian Gulf War resulted in injuries of US Coalition personnel by fragments of depleted uranium (DU). Fragments not immediately threatening the health of the individuals were allowed to remain in place, based on long-standing treatment protoc...

Gaucher, D.; Chadee, K., 2003: Prospect for an Entamoeba histolytica Gal-lectin-based vaccine. Entamoeba histolytica is the aetiological agent of invasive amoebiasis, the third leading parasitic cause of mortality in the world. The disease can be easily cured by chemotherapy; however, prevention, mainly in the form of vaccination, could gre...

Roy, G.; Burton, J.; Lecomte, J.; Boudreault, A., 1983: Role des passeriformes dans l'ecologie du virus grippal. Passerine birds (267) distributed among 37 spp. were netted during spring 1980 and summer 1981 in the Laurentian and Montreal Canada areas. All the cloacal swabs collected at that time were free of influenza viruses. Three and 5 days after oral ad...

Loria, G.; D'Arrigo, G.; D.S.efano, F., 1971: On the palm-chin reflex in parkinsonian patients treated with L-adamantyl-amine hydrochloride (amantadine). Rivista di Neurobiologia 17(3): 379-387