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Effects of nicotinic acid therapy on high-density lipoprotein metabolism in type II and type IV hyperlipoproteinaemia

, : Effects of nicotinic acid therapy on high-density lipoprotein metabolism in type II and type IV hyperlipoproteinaemia. Biochimica et Biophysica Acta 618(1): 53-62

The influence of pharmacologic doses of nicotinic acid [NA] on HDL [high density lipoprotein] metabolism in 6 type II and 4 type IV hyperlipoproteinemic subjects was investigated. Although the drug lowered the level of triacylglycerol and VLDL[very low density lipoprotein]-cholesterol in the type II group, it produced no significant change in the plasma concentrations of LDL[low density lipoprotein]-cholesterol, HDL-cholesterol, HDL2, HDL3 and apolipoproteins A-I and A-II. Separation of the group into IIa and IIb subtypes revealed a marked divergence in their response to treatment. The former exhibited a substantial reduction in plasma triacylglycerol and a striking rise in the HDL2/HDL3 ratio while in the latter these parameters were little affected by the drug. In the type IV subjects NA lowered both cholesterol and triacylglycerol levels, the former deriving from a reduction in the level of that lipid associated with VLDL. HDL-cholesterol rose significantly in this group, as did both HDL2 and HDL3. These changes were accompanied by an increase in plasma apolipoprotein A-I due to a fall in its fractional rate of catabolism. The plasma apolipoprotein A-II level was unaffected by treatment. These differing responses to NA treatment may reflect a differential effect of the drug on triacylglycerol and VLDL metabolism in normo- and hypertriglyceridemic subjects.


PMID: 6990991

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