geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nifedipine in achalasia and in patients with high-amplitude peristaltic esophageal contractions


, : Effects of nifedipine in achalasia and in patients with high-amplitude peristaltic esophageal contractions. JAMA 252(13): 1733-1736

We studied the esophageal effects of nifedipine in 20 patients with achalasia (20 mg sublingually) and nine patients with high-amplitude peristaltic esophageal contractions (nutcracker esophagus) (20 mg orally). In patients with achalasia, nifedipine decreased lower esophageal sphincter (LES) pressure by approximately 30%. In ten patients with achalasia, plasma nifedipine concentrations were 45.3 +/- 17.7 and 57.4 +/- 12.8 ng/mL (means +/- SEM) at 30 and 60 minutes, respectively, after drug administration. In patients with nutcracker esophagus, nifedipine decreased LES pressure by approximately 50% and contraction amplitude in the body of the esophagus by approximately 25%. After comparison was made with our previous results in normal subjects, we concluded that (1) nifedipine decreased LES pressure in patients with achalasia to a similar extent to that noted in normal subjects; (2) plasma concentrations measured after 20 mg of nifedipine given sublingually to achalasic patients were similar to those found under similar circumstances in normal subjects; and (3) nifedipine decreased LES pressure and contraction amplitude in patients with nutcracker esophagus to a greater extent than was found in normal subjects. These results suggest that double-blind, placebo-controlled clinical trials of nifedipine in the treatment of achalasia or nutcracker esophagus are indicated.

US$29.90

PMID: 6471300


Other references

Keydel, F., 1975: Agronomic exploitation of the genetic basis of yield and its extension by breeding. Possibilities of improving grain yield in cereals by breeding are reviewed with reference to published work on yield components, especially ear fertility and the various physiological processes affecting yield.

Zhang, J.-xia.; Song, D.-xiang., 2001: One new spider species of the genus Gnaphosa (Araneae: Gnaphosidae) from China. Journal of Hebei University Natural Science Edition. Mar; 211: 78-79

Deng, E.; Nguyen, N.T.; Hild, Fédéric.; Hamilton, I.E.; Dimitrakis, G.; Kingman, S.W.; Lau, P-Li.; Irvine, D.J., 2016: Molecular Differentiated Initiator Reactivity in the Synthesis of Poly(caprolactone)-Based Hydrophobic Homopolymer and Amphiphilic Core Corona Star Polymers. Macromolecules that possess three-dimensional, branched molecular structures are of great interest because they exhibit significantly differentiated application performance compared to conventional linear (straight chain) polymers. This paper repo...

James, W.D.; Odom, R.B., 1980: The role of the myo fibroblast in dupuytrens contracture. A [patient] case report of Dupuytren's contracture illustrates the functional and light microscopic and EM characteristics of the myofibroblast. The myofibroblast is associated with an increasing number of diseases and is believed to be a mor...

Anonymous, 1943: Residue of oil seeds as feeding-stuffs. Sunflower seed meal. In the winter of 1942-43 large quantities of Russian sunflower seed were ground in German oil mills, the fat being removed by means of benzine. The sunflower seed meal obtained as a by-product was allotted to the use of domest...

Krüger, T.; Forkavets, O.; Veseli, K.; Lausberg, H.; Vöhringer, L.; Schneider, W.; Bamberg, F.; Schlensak, C., 2016: Ascending aortic elongation and the risk of dissection. Unlike aneurysm formation, the role of ascending aortic elongation in the pathogenesis of Type A aortic dissection (TAD) is largely unclear. We investigated the morphology of healthy, dissected and predissection aortas with a focus on ascending ao...

Ziliotto, U.; Scotton, M., 1998: Effects of liquid fertilizers, incorporation of crop residues and mineral fertilizers on the soil and yield of continuous maize (1977-96). In a field trial in 1977-96 in Legnaro, Italy, continuous maize was given liquid manure and/or NPK fertilizer or no fertilizer, with or without incorporation of crop residues. Grain and straw yields were lower with liquid than mineral fertilizer,...

Keddeman, W., 1980: Livestock development in semi-arid rangelands: monitoring the performance of coast ranches in Kenya. Over the past five to ten years investments in excess of $10 mill. have been made in the development of livestock production in the coastal rangelands of Kenya. The study uses a monitoring approach developed by the International Livestock Centre f...

Lowenberg, E.; Vargas García, C.; Rodríguez, C., 1981: Prevention of premature birth by uterus-inhibiting drugs. Ginecologia Y Obstetricia de Mexico 49(296): 377-391

Marek, T.; Ndiaye, B., 2002: At the start of the 21st century, we have the means to reduce malnutrition in sub-Saharan Africa, but will we do it?. The number of malnourished children in Africa continues to increase. It has been proven that such tendency could be stopped or even reversed if the lessons learnt from successful community nutrition programs were applied. The authors do not deny t...