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Effects of nifedipine on lactate metabolism in ischemic cardiopathy. Evaluation by atrial pacing

, : Effects of nifedipine on lactate metabolism in ischemic cardiopathy. Evaluation by atrial pacing. Minerva Medica 71(38): 2773-2779

10 patients with documented ischaemic heart disease were undergone to atrial pacing (AP) before and after administration of nifedipine. The lactate utilization (%L), ischaemic ST, angor were tested in the same conditions before and after the drug. Six patients presented negative lactate utilization (-%L) during AP before the drug and four had decreased %L during recovery. -%L was removed by the drug, in those without -%L nifedipine is able to provocate the same paradoxically. Nevertheless angor disappears n all cases while the ischaemic ST is irregulary eliminated. Paradoxical -%L after nifedipine was not assumed as result of damage of the coronary flow, as ischaemic ST and angor disappear. Probably this is the sign of byochemical block of piruvate-deydrogenasy due to the Ca++ antagonist action of nifedipine. Nifedipine favorable action was explained by the increased %L in patients with low %L during recovery time, that is expression of a increased aerobic metabolism.


PMID: 7432686

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