geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nifedipine on lactate metabolism in ischemic cardiopathy. Evaluation by atrial pacing


, : Effects of nifedipine on lactate metabolism in ischemic cardiopathy. Evaluation by atrial pacing. Minerva Medica 71(38): 2773-2779

10 patients with documented ischaemic heart disease were undergone to atrial pacing (AP) before and after administration of nifedipine. The lactate utilization (%L), ischaemic ST, angor were tested in the same conditions before and after the drug. Six patients presented negative lactate utilization (-%L) during AP before the drug and four had decreased %L during recovery. -%L was removed by the drug, in those without -%L nifedipine is able to provocate the same paradoxically. Nevertheless angor disappears n all cases while the ischaemic ST is irregulary eliminated. Paradoxical -%L after nifedipine was not assumed as result of damage of the coronary flow, as ischaemic ST and angor disappear. Probably this is the sign of byochemical block of piruvate-deydrogenasy due to the Ca++ antagonist action of nifedipine. Nifedipine favorable action was explained by the increased %L in patients with low %L during recovery time, that is expression of a increased aerobic metabolism.

US$29.90

PMID: 7432686


Other references

Iijima, T.; Iwao, Y.; Yorozu, T.; Shimizu, M., 2006: Questionnaire survey of anesthesiologists' opinion regarding the Japanese guidelines for transfusion. Anesthesiologists' opinions regarding the Japanese guidelines for transfusion were surveyed. From December 28, 2004 to January 28, 2005 a questionnaire survey was performed in 958 hospitals registered with the Japanese Society for Anesthesiol...

Grokhol' skii, A.I., 1980: Soya bean oilmeal in diets for pigs. For 160 days, pigs were fed on a diet with soya bean oilmeal containing urease 0.0 to 0.1, 0.1 to 0.2, 0.2 to 0.3 or 0.3 to 0.5%. Urease at up to 0.3% did not cause any adverse effect on gain or feed conversion efficiency. Processing of soya bean...

Mimura, M., 2007: Depression and apathy in Parkinson disease. Although Parkinson disease (PD) is primarily a condition of motor symptoms, an increasing amount of research has indicated that non-motor symptoms including cognitive and emotional deficits are observed even in the earliest stage of the disease. I...

Jastak, J., 1949: Psychometric personality traits. Delaware Medical Journal 21(8): 165-169

Asanuma H.; Kosar E.; Tsukahara N.; Robinson H., 1985: Modification of the projection from the sensory cortex to the motor cortex following the elimination of thalamic projections to the motor cortex in cats. Examination of the projection from area 2 of the sensory cortex to the motor cortex revealed substantial changes following lesion of the ventrolateral nucleus of the thalamus. These observed changes were as follows. (1) The polarity of the evoked...

Baird A.J.; Horn D.P., 1994: Modelling beach groundwater dynamics in response to tidal forcing. Eos, Transactions, American Geophysical Union: 4, Suppl., Pages 335. 1994.

Gagnon, F.; Jarvik, G.P.; Motulsky, A.G.; Deeb, S.S.; Brunzell, J.D.; Wijsman, E.M., 2003: Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment. The APOA1-C3-A4-A5 gene complex encodes genes whose products are implicated in the metabolism of HDL and/or triglycerides. Although the relationship between polymorphisms in this gene cluster and dyslipidemias was first reported more than 15 years...

Montaner, J.; Chacón, P.; Krupinski, J.; Rubio, F.; Millán, M.; Molina, C.A.; Hereu, P.; Quintana, M.; Alvarez-Sabín, J., 2007: Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial. Although statins are being used for secondary prevention of ischemic stroke, recent experimental data have shown new pleiotropic effects of these drugs responsible for their role in neuroprotection. We conducted a pilot, double-blind, randomized,...

Rydell, H.; Krützen, L.; Simonsen, O.; Clyne, N.; Segelmark, Mårten., 2014: Excellent long time survival for Swedish patients starting home-hemodialysis with and without subsequent renal transplantations. Survival for patients on dialysis is poor. Earlier reports have indicated that home-hemodialysis is associated with improved survival but most of the studies are old and report only short-time survival. The characteristics of patient populations a...

Guilhaumon, H., 1987: Des mammouths a Ottawa. Quebec Science, 263: 30-33