+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nifedipine on myocardial energy balance in experimental coronary vasoconstriction and occlusion

, : Effects of nifedipine on myocardial energy balance in experimental coronary vasoconstriction and occlusion. Journal of Cardiovascular Pharmacology 4(1): 111-115

The effect of nifedipine on the myocardial energy demand--supply imbalance caused by vasopressin-induced vasoconstriction, coronary occlusion, and their combined action was studied in isolated perfused rabbit hearts using the method of NADH fluorometry. Nifedipine (0.015 microgram/ml) completely prevented the development of NAD/NADH imbalance caused by coronary vasospasm. The role of vasoconstriction as an addition to coronary occlusion was very small in the development of regional energy imbalance and the vasopressin-induced detrimental effect was prevented by nifedipine. Energy imbalance caused by the occlusion alone was only partially improved by the drug. There was a delay in the development of energy imbalance and reduction in the final degree of NADH fluorescence response to the occlusion (97 +/- 8% vs. 66 +/- 9%, p less than 0.05).


PMID: 6176785

Other references

Baumgartner, M.F.; Tarrant, A.M., 2016: The Physiology and Ecology of Diapause in Marine Copepods. NlmCategory="UNASSIGNED">Diapause is a type of dormancy that requires preparation, typically precedes the onset of unfavorable conditions, and necessitates a period of arrest before development can proceed. Two ecologically important...

Le, H.M.; Lifshitz, I.; Smith, M.L.; Pinanong, P.; Lee, S.M.; Becker, D.P.; Hovda, D.A., 1994: Uncoupling of glucose metabolism and blood flow in degenerating cortical and hippocampal areas following unilateral cortical contusion. Society for Neuroscience Abstracts 20(1-2): 196

Toyohara, K.; Mashima, Y.; Hasegawa, T.; Honda, H.; Shimoto, S.; Sakai, O., 1993: Effects of amantadine on high energy phosphate compounds in patients with cerebral infarcts as estimated by 31P-MRS. The pharmacological effects of amantadine hydrochloride (AD) on high energy phosphate metabolism in the brain were examined in 4 patients with chronic cerebral infarction and 5 healthy controls by 31P-magnetic resonance spectroscopy (MRS). Spectra...

Rael, E.D.; Martinez, M.; Molina, O., 1992: Isolation of a fibrinolytic protease, M4, from venom of Crotalus molossus molossus (northern blacktail rattlesnake). M4, a fibrinolytic protease, was isolated from the venom of Crotalus molossus molossus. It has a pI of 9.6 and a molecular weight of 27,000. The protease hydrolyzes the A.alpha. and B.beta. chains of fibrinogen, and the .alpha. and .beta. chains o...

Plant A.R.; Evans N.A., 1982: Quantitative aspects of the host parasite relationship between larval schistosomes and their intermediate hosts. Parasitology 85(2): LXX

Wei Li; Cailin Lei; Zhijun Cheng; Yulin Jia; Dongyi Huang; Jiulin Wang; Jiankang Wang; Xin Zhang; Ning Su; Xiuping Guo; Huqu Zhai; Jianmin Wan, 2008: Identification of SSR markers for a broad-spectrum blast resistance gene Pi20(t) for marker-assisted breeding. The Pi20(t) gene was determined to confer a broad-spectrum resistance against diverse blast pathotypes (races) in China based on inoculation experiments utilizing 160 Chinese Magnaporthe oryzae (formerly Magnaporthe grisea) isolates, among which...

Mccormick, Rd, 1977: A product management approach to controlling quality of refrigerated foods. Food product development: 11 (8) 14

Elema, R.K.; Sas, L.J.M., 1972: What does it cost to transport fruit from the farm to market?. Factors affecting transport costs for apples and pears are summarized, based on a survey of about 50 farms. A detailed analysis is given of the costs involved in transporting fruit for distances of 3 to 20 km, in loads of 1.5 to 6 tons, with and w...

Horie, M., 2011: Fitness for employment. Rinsho Byori. Japanese Journal of Clinical Pathology Suppl 146: 1-28

Sandhu, S.Singh., 2014: Innovation, invention, and IPR in biotechnology: current scenario. Recent Patents on Biotechnology 7(3): 171-171