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Effects of nifedipine on resistance vessels, arteries and veins in man


, : Effects of nifedipine on resistance vessels, arteries and veins in man. British Journal of Clinical Pharmacology 10(5): 433-438

1 The effect of nifedipine on peripheral blood vessels has been studied in man. 2 Nifedipine induced dilatation of the forearm resistance vessels when given either by local intra-arterial infusion or sublingually (10 mg). 3 Local infusion of the drug did not relax hand veins preconstricted by infusion of noradrenaline and neither local infusion nor sublingual administration prevented constriction mediated by the sympathetic nervous system. Nifedipine was, however, a potent inhibitor of hand vein contractions induced by high concentrations of potassium provided that the noradrenergic component of the response was suppressed by simultaneous infusion of phentolamine. 4 Sublingual nifedipine (10 mg) did not dilate the elbow collateral arteries. 5 The effects of nifedipine on peripheral blood vessels are similar, but not identical, to those of verapamil. The pattern of action, with dilatation of resistance vessels but not capacitance, resembles that of hydralazine rather than glyceryl trinitrate and this suggest that nifedipine may prove useful in the treatment of hypertension.

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PMID: 7437254


Other references

Kumar M.R.; Canolty N.L., 1980: Influence of wheat legume mixtures at different protein concentrations on weight and composition of weanling rats. Federation Proceedings 39(3): ABSTRACT 1573

Geissler, D.; Martinek, A.; Margolis, R.U.; Margolis, R.K.; Skrivanek, J.A.; Ledeen, R.; Konig, P.; Winkler, H., 1977: Composition and biogenesis of complex carbohydrates of ox adrenal chromaffin granules. The predominant sugars in the glycoproteins of the membrane are mannose, galactose and N-acetylglucosamine, whereas galactose, N-acetylgalactosamine and sialic acid are present in high concentration in the glycoproteins of the soluble content. Mos...

Reynders, L.; Vlassak, K., 1976: Nitrogen fixing Spirillum species in Belgian soils. Nitrogen-fixing Spirillum was isolated on a nitrogen-free semi-solid nutrient medium from more than half of a total of 38 samples representing a wide range of soil types. The organism was present under a wide variety of plant covers. Biochemical d...

Nel, Jacques, 2006: Microlepidopteres nouveaux ou peu connus de la faune de France (Lepidoptera, Adelidae, Tineidae, Cosmopterigidae, Elachistidae et Gelechiidae). Six species of Microlepidoptera are mentioned new from France : Cauchas albiantennella (Burmann, 1943) (Adelidae), Infurcitinea vartianae Petersen, 1962 (Tineidae0, Elachista galactitella (Eversmann, 1844) (Elachistidae), Monochroa divisella (Doug...

Farrugia, A.; Grasso, S.; Douglas, S.; Harrap, R.; Oates, A.; Young, I.; James, J.; Whyte, G., 1992: Modulation of fibrinogen content in cryoprecipitate by temperature manipulation during plasma processing. In routine blood bank production of single-donation cryoprecipitate, the introduction of 16-hour hold at 4 degree C, with the frozen plasma units packed into polystyrene containers, resulted in plasma prethaw temperatures of -4 degree C to -8 degr...

Freund, E.; Graef, W., 1968: ZytoarcMtektonik des Mittelhirnes beim Meerschweinchen (Cavia porcellus L.). Archiv fuer Experimentelle Veterinaermedizin, 22: 815-829

Yu, D.S.F.; Lee, D.T.F.; Stewart, S.; Thompson, D.R.; Choi, K-Chow.; Yu, C-Man., 2015: Effect of Nurse-Implemented Transitional Care for Chinese Individuals with Chronic Heart Failure in Hong Kong: A Randomized Controlled Trial. To determine the effect of nurse-implemented transitional care (TC) on readmission and mortality rates in Chinese individuals with chronic heart failure (CHF) in Hong Kong. Single-center randomized controlled trial of TC versus usual care (UC). Un...

Ueno, S.; Mayahara, H.; Ueck, M.; Tsukahara, I.; Ogawa, K., 1983: Ultracytochemical localization of ouabain-sensitive, potassium-dependent p-nitrophenylphosphatase activity in the lacrimal gland of the rat. The electron-microscopic localization of ouabain-sensitive, K-dependent p-nitrophenylphosphatase (K-NPPase) activity of the Na - K-ATPase complex was studied in the exorbital lacrimal gland of the untreated rat with the use of a newly developed on...

Mehta, S.C.; Rice, K.; Palzkill, T., 2016: Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability. The spread of β-lactamases that hydrolyze penicillins, cephalosporins and carbapenems among Gram-negative bacteria has limited options for treating bacterial infections. Initially, Klebsiella pneumoniae carbapenemase-2 (KPC-2) emerged as a widesp...

Kucera, A.; Batek, F.; Minarik, L.; Kucerova, V., 1959: On the effect of pentamethonium on the course of interoceptive changes of white and red blood pictures in rabbits. Ceskoslovenska Fysiologie 8: 418-419