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Effects of nimbidin on acute and chronic gastro-duodenal ulcer models in experimental animals

, : Effects of nimbidin on acute and chronic gastro-duodenal ulcer models in experimental animals. Planta Medica 50(2): 143-146

Nimbidin, an ester of terpenic origin, which forms the major bitter principle isolated from the oil of seed scernels of Azadirachta indica (Meliaceae), possessed significant anti-ulcer potential in various experimental models. Anti-ulcer studies (preventive tests) revealed very significant protective effects of the test drug in doses of 20-40 mg/kg (p.o. [orally]) in acetylsalicylic acid, stress, serotonin and indomethacin induced gastric lesions in rats. The test drug also afforded remarkable protection in both types of chemically induced duodenal lesions in rodents [guinea pig]. In ulcer healing tests, nimbidin significantly enhanced the healing process in acetic acid induced chronic gastric lesions in albino rats and dogs.


PMID: 6473546

DOI: 10.1055/s-2007-969654

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