geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nine different gastrointestinal polypeptides on vascular smooth muscle in vitro


, : Effects of nine different gastrointestinal polypeptides on vascular smooth muscle in vitro. Acta Physiologica Scandinavica 110(1): 89-94

Nine polypeptides of gastrointestinal origin were tested for their possible effect on vascular smooth muscle of the rat portal vein. The substances tested were bombesin, caerulein, glucagon, insulin, pentagastrin, secretin, somatostatin, substance P and vasoactive intestinal polypeptide (VIP). Cumulative dose-response relations of integrated mechanical activity (mean tension) were obtained with maximal concentrations of the various peptides of 1-10 microgram/ml. Within this concentration range, only substance P and VIP showed clearcut effects; substance P causing contraction and VIP relaxation. The dose of substance P needed to produce contraction was high (ED50 greater than 1 microM) so that the physiological importance of this response is doubtful. On the other hand, ED50 for the relaxing effect of VIP was about 15 nM, which is in accordance with concentrations reported to produce significant vasodilatation in vivo. The results support the view that vascular effects which have been reported to occur in response to the other 7 peptides are mainly of indirect origin and not mediated via direct action on vascular smooth muscle.

US$19.90

PMID: 6162366

DOI: 10.1111/j.1748-1716.1980.tb06634.x


Other references

Simancas, R.; Corzo, P.; Coronel, C., 1987: Seven years of observations on grape varieties (Vitis vinifera) in Venezuela. Studies of agronomic and quality characters over 6-12 growth cycles showed that the cultivars Danam and Ribol were promising for table grapes, while French Colombard, Ugni Blanc (= Trebianno Toscano) and Inzolio were best for wine.

Hrycek, A.; Stieber, M.; Zielińska, H.; Flakus, L., 1995: Study of nitroblue tetrazolium reduction by granulocytes in workers handling x-ray equipment. In 44 persons (25 women and 15 men), workers handling X-ray equipment in X-ray laboratories the ability was studied of nitroblue tetrazolium (NBT) reduction by neutrophils. The obtained results were compared with a control group. Besides that subg...

Elleder, M., 1987: Niemann-Pick disease, 1914-1986. Review of the development of the present state of knowledge. Casopis Lekaru Ceskych 126(13): 393-398

Yoshimura S.; Shimoji E.; Ohara M.; Kodaira K.; Otsubo K., 1976: Quantitative and noninvasive method for estimating the grade of cerebral arterio sclerosis. Japanese Journal of Medicine 15(4): 361-362

Hilt, M.; Kohler, F., 1993: Corticaria lateritia Mannh. - neu fur Deutschland. Anmerkungen zur Okologie der verwandten Corticaria-Arten und andere bemerkenswerte Totholzkaferfunde aus dem Allacher Forst bei Munchen. Entomologische Nachrichten und Berichte. 30 Dezember; 374: 257-258

Griffin, L.S.; Boivin, M.A., 2016: A Hole in the Wall. Annals of the American Thoracic Society 13(9): 1651-1653

Cheylan Gilbert; Sigal Jacques, 1954: Resultats geologiques et micropaleontologiques du sondage d'El Krachem (hauts plateaux algerois); description de quelques especes nouvelles. Describes the Miocene and Cretaceous series traversed by a boring at El Krachem in the high plateau region of Algeria, and compares them with beds of the Tellian facies to the north and with those of the Atlas ranges to the south. The microfaunas...

García-Salido, A.; Nieto-Moro, M.; Iglesias-Bouzas, Mía.Isabel.; González-Vicent, M.; Serrano-González, A.; Casado-Flores, J., 2015: Critically ill pediatric hemato-oncology patient: What we do is what we should do?. Primary objective, to describe the management and monitorization of critically ill pediatric hemato-oncology patient (CIPHO) in the Spanish pediatric intensive care units (PICU). Secondary objective, through a literature review, to identify possib...

Klein, G., 1951: Postmortem statistics on gastric and duodenal ulcer. Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten 11(4): 153-162

Czapla, Z.; Liczbińska, Gżyna., 2015: Height as an indicator of economic status in the Polish territories under Russian rule at the turn of the 19th to 20th century. Height is regarded as one of the indicators of environmental stress at population level, being an excellent barometer of standard of living. The aim of this study was to describe diversity in height among populations living in different regions of...