+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nisoldipine on endothelin-1- and angiotensin II-induced immediate/early gene expression and protein synthesis in adult rat ventricular cardiomyocytes

, : Effects of nisoldipine on endothelin-1- and angiotensin II-induced immediate/early gene expression and protein synthesis in adult rat ventricular cardiomyocytes. Journal of Cardiovascular Pharmacology 24(1): 13-16

The cellular mechanisms by which dihydropyridine-type calcium antagonists lead to regression of hypertension-related cardiac hypertrophy have not been clarified. We previously showed that angiotensin II (AII) and endothelin-1 (ET-1) induce protein synthesis in isolated adult rat cardiomyocytes, probably through protein kinase C (PKC) as second messenger and the gene product of the early growth response gene-1 (Egr-1) as third messenger. We now show that the dihydropyridine derivative nisoldipine inhibits AII- and ET-1-induced protein synthesis at low concentrations (IC50 7.5 nM for 0.1 microM ET). Induction of c-fos and Egr-1 mRNA by AII and ET was completely blocked by nisoldipine. Therefore, nisoldipine may influence the signal transduction pathway, i.e., through PKC. These results provide a potential pressure-independent mechanism by which nisoldipine may influence development of cardiac hypertrophy.


PMID: 7521477

Other references

Fielden, A.L.; Sillence, E.; Little, L.; Harris, P.R., 2016: Online Self-Affirmation Increases Fruit and Vegetable Consumption in Groups at High Risk of Low Intake. This study tested the efficacy of self-affirmation in promoting fruit and vegetable consumption in a sample of participants comprising two groups at high risk of low consumption: young adults and mothers of school-aged children with low social eco...

Loughlin, S., 2014: The danger of unintended consequences. Biomedical Instrumentation & Technology 47(6): 442-442

Chiu, Y-Jui.; Cho, S.Hwan.; Mei, Z.; Lien, V.; Wu, T-Feng.; Lo, Y-Hwa., 2013: Universally applicable three-dimensional hydrodynamic microfluidic flow focusing. We have demonstrated a microfluidic device that can not only achieve three-dimensional flow focusing but also confine particles to the center stream along the channel. The device has a sample channel of smaller height and two sheath flow channels...

Reynoso, L.; Muñoz, M.C.; Rosas, D.; Sánchez, R.A.; Aznar, R., 1979: Use and acceptance of the "Paper Pill" among an urban clinic population. A randomized, crossover study comparing the acceptability of two presentations of the same oral contraceptive, a paper formulation and the conventional tablet, was carried out among two-hundred-and-seventy women attending two urban family planning...

Morganstern, P.S., 1990: Court-ordered caesarean sections: round II. Healthspan 7(6): 10-11

Hadley, P.B., 1913: Studies on inheritance in poultry; i. The constitution of the White Leghorn breed. Agric Exp Sta Rhode Island Kingston Bull, 155 151-216

Abbasi, K., 2015: How NICE turned into a Teletubby. Journal of the Royal Society of Medicine 108(6): 207-207

Alvisi, C.; Loperfido, E., 1963: Diagnostic And Prognostic Value Of Gas Encephalography In Infantile Patients With Cerebral Paralysis. Il Lattante 34: 381-392

Denny, William A., 2003: Drugs that target tumour hypoxia The promise and the challenge. British Journal of Cancer 88(Supplement 1): S2, July

Howell, J.A.S., 2007: Carboxylate lability as a factor in the Rh2(carboxylate)4-catalysed cyclopropenation and cyclopropanation of alkynes and alkenes. The mechanism of Rh(2)(carboxylate)(4)-catalysed cyclopropenation and cyclopropanation via two different pathways has been investigated computationally. The two pathways either (a) conserve the Rh(2)O(8) framework, with initial coordination of CH(...