geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nitrogen dioxide exposure on prostacyclin synthesis in lung and thromboxane A2 synthesis in platelets in rats


, : Effects of nitrogen dioxide exposure on prostacyclin synthesis in lung and thromboxane A2 synthesis in platelets in rats. Prostaglandins 26(2): 303-310

Effects of nitrogen dioxide (NO2) exposure on prostacyclin (PGI2) synthesis in the rat lung and thromboxane A2 (TXA2) synthesis in the platelets were studied. Male Wistar rats were exposed to 10 ppm NO2 for 1, 3, 5, 7 and 14 days. PGI2 synthesizing activity of homogenized lung decreased. The damage of PGI2 synthesizing activity reaches its maximum at 3 days. At 14 days, PGI2 synthesizing activity returned to the normal level. The activity of PGI2 synthetase decreased significantly. The formation of lipid peroxides due to NO2 exposure may cause the depression of PGI2 synthesizing activity of lung. On the other hand, platelet TXA2 synthesizing activity increased. This increased TXA2 synthesizing activity lasted at least till 3 days. Then, it returned to the normal level. The counts of platelet were decreased significantly by 1, 3, 5 and 7 days NO2 exposure. Then the decreased counts of platelet returned to the normal level at 14 days NO2 exposure. These results indicate that the depression of PGI2 synthesizing activity of lung by NO2 exposure cause an increase in TXA2 synthesizing activity of platelets. It may contribute to induce platelet aggregation and to the observed decrease in the number of platelets during NO2 exposure.

US$29.90

PMID: 6359274


Other references

Schmitz, S.A.; Hohenbleicher, H.; Koennecke, H.C.; Offermann, R.; Offermann, J.; Branding, G.; Wolf, K.J.; Distler, A.; Sharma, A.M., 1999: Neurogenic hypertension. A new MRI protocol for the evaluation of neurovascular compression of the cranial nerves IX and X root-entry zone. OBJECTIVE. Neurovascular compression of the rostral ventrolateral medulla (RVLM) has been implicated in the pathogenesis of essential hypertension. Although MRI has been widely used to evaluate the morphologic relation of structures in this region...

Kim, S.; Boege, U.; Krishnaswamy, S.; Minor, I.; Smith, T.J.; Luo, M.; Scraba, D.G.; Rossmann, M.G., 1990: Conformational variability of a picornavirus capsid: pH-dependent structural changes of Mengo virus related to its host receptor attachment site and disassembly. The structure of Mengo virus had been determined from crystals grown in the presence of 100 mM phosphate buffer at pH 7.4. It is shown that Mengo virus is poorly infectious at the phosphate concentration similar to that in which it was crystallize...

Munsch, T.E.; Tran, J.D.; Li, B.; Stalker, R.A.; Beatty, A.; Warmuth, R., 2001: Synthesis of constrained lysine derivatives. Abstracts of Papers American Chemical Society 221(1-2): ORGN 110

Kitazawa, M.; Oddo, S.; Yamasaki, T.R.; Green, K.N.; LaFerla, F.M., 2005: Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. Inflammation is a critical component of the pathogenesis of Alzheimer's disease (AD). Although not an initiator of this disorder, inflammation nonetheless plays a pivotal role as a driving force that can modulate the neuropathology. Here, we...

Papillon J., 1984: New prospects in the conservative treatment of rectal cancer. Conservative treatment of rectal cancer is applicable only to limited tumors that are assumed to have no lymphatic spread; these are well or moderately well differentiated adenocarcinomas confined to the bowel wall, without palpable pararectal met...

Frankenberger, M.; Ziegler-Heitbrock, H.W., 1998: LPS tolerance in monocytes/macrophages: three 3' cytosins are required in the DNA binding motif for detection of upregulated NF-kappa B p50 homodimers. When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS. Tolerant cells still express the CD14 receptor...

Saban R.; Zizen M T.I.; Rinjard J.; Christov K.; Strazielle L.; Cabanis E.A., 1983: In vivo cephalic computed tomography of macaca irus a study using the neuro ocular plane comparison with man. Computed tomographic exploration by neuroocular plane [N.O.P.] in vivo of a Macaca's head is compared with man. The N.O.P. was recognized from many works. It permitted a biometric approach and a very precise morphologic study of the brain and...

Webb, D.G., 1991: Effect of predation by juvenile pacific salmon on marine harpacticoid copepods i. comparisons of patterns of copepod mortality with patterns of salmon consumption. The impact of predation by juvenile chum Oncorhynchus keta (Walbaum) and pink O. gorbuscha (Walbaum) salmon on harpacticoid copepods inhabiting a shallow subtidal seagrass Zostera marina L. bed on Roberts Bank, British Columbia, Canada, was examin...

Krysiak, R.; Handzlik-Orlik, G.; Okopien, B., 2012: Endocrine symptoms as the initial manifestation of Wilson's disease. Wilson's disease is a rare genetic disorder of copper metabolism. The difference in copper tissue accumulation is responsible for the various clinical manifestations of this disorder. If left untreated, Wilson's disease progresses to hep...

Rao A.R.; Gur I.S.; Bhatnagar H.L., 1982: Tosylation of cellobiose and thermal analysis of the product. Journal of the Indian Chemical Society 62(8): 595-599