geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nitroglycerin and nitroprusside on the uterine vasculature of gravid ewes


, : Effects of nitroglycerin and nitroprusside on the uterine vasculature of gravid ewes. Anesthesiology 52(5): 390-394

The effects of nitroglycerin (TNG) and sodium nitroprusside (SNP) on mean aortic pressure (MAP), uterine blood flow (UBF), uterine vascular conductance (UVC), and pulse rate (PR) were compared when the two agents were infused to prevent and treat hypertension induced by norepinephrine (NE) in gravid ewes. When infused alone, TNG, 19 microgram/kg/min, decreased MAP 19 per cent and increased PR 33 per cent from control values (P less than 0.05), but did not significantly change UBF or UVC. In comparison, SNP, 3 microgram/kg/min, decreased MAP 20 per cent and increased PR 43 per cent (P less than 0.05), and did not significantly change UBF or UVC. When given alone, four successive 2-min infusions of NE produced dose-related increase in MAP and decreases in UBF, UVC, and PR; values were significantly different from control with the two higher doses of NE. Although MAP, UBF, and UVC were still significantly changed from control levels when NE was given in the presence of the above infusions of TNG or SNP, MAP was lower and UBF and UVC were higher compared with when NE was given alone (P less than 0.05). When given to control hypertension induced by a continuous infusion of NE, TNG or SNP produced uterine vasodilatation and significantly increased UBF. Nitroglycerin and SNP were equally effective in counteracting the maternal hypertension and antagonizing the uterine vascular effect of NE. It is concluded that TNG and SNP counteract uterine vasoconstriction resulting from alpha-adrenergic stimulation and do not produce a shunt of blood flow away from the uterine vasculature when used to control hypertension in gravid ewes.

US$29.90

PMID: 6769361


Other references

Haines, F.M., 1927: A method of propelling air round small enclosed circuits. Journal of Physiology 63(1): 94-96

Sawyers, C.L., 2006: Making progress through molecular attacks on cancer. The success of kinase inhibitor therapy in chronic myeloid leukemia (CML) has validated the long-held thesis in the cancer research community that a precise molecular understanding of cancer can directly affect cancer therapy. Now that several yea...

Derlin, T.; Büsche, G.; Kröger, N., 2015: Diagnostic value of 18F-FDG-PET/CT for monitoring myelofibrosis after allogeneic stem cell transplantation. Myelofibrosis is a rare hematopoietic stem cell neoplasm leading to marked bone marrow fibrosis and ineffective hematopoiesis. We report a case highlighting the potential role of ¹⁸F fluorodeoxyglucose (FDG) positron emission tomography/compute...

González-De-Olano, D.; González-Mancebo, E.; Mohedano-Vicente, E.; Gandolfo-Cano, M.; Bartolomé, B., 2013: Pollen-food syndrome involving allergy to tiger nut. Journal of Investigational Allergology & Clinical Immunology 23(3): 197-198

Voroshilov, V.I.; Trukhmanov, B.G., 1976: Investigation of some problems of virology and creation of means of specific prophylaxis of virus infections in the institute of poliomyelitis and virus encephalitis, academy of medical sciences of the USSR. Several great problems are clearly distinguished in the development of the Soviet medical virology. The team of the Institute of Polliomyelitis and Virus Encephalitis of the AMS of the USSR actively participates in the study of these problems. The...

Montanarella Luca, 2004: Polices for a sustainable use of the soil resource. International Geological Congress, Abstracts = Congres Geologique International, Resumes 32, Part 1: 33

Rapson, A.M., 1961: Food of some tropical predaceous fish, including sharks, from net and line fishing records. Pacific Sci Congr Abstr Symp Pap 10: 178-180

Samuels, M.A.; Mesko, T.; Keisch, M.E.; Kopacka, K., 2002: Safety and feasibility of subcutaneous amifostine administration prior to radiation therapy. International Journal of Radiation Oncology Biology Physics 54(2 Supplement): 287

Hambor J.E.; Hauer C.A.; Shu H K.; Groger R.K.; Kaplan D.R.; Tykocinski M.L., 1988: Use of an epstein barr virus episomal replicon for anti sense rna mediated gene inhibition in a human cytotoxic t cell clone cd8. A methodology was developed for stable gene transfer into cloned nontransformed human T lymphocytes. Stable high-level gene expression was achieved in cloned human T cells by using a self-replicating Epstein-Barr virus (EBV) episomal replicon. A c...

Gannon, T.; Ansbro, A.R.; Burns, R.P., 1991: Incineration of hazardous wastes. Glaxo has practiced incineration of liquid and gaseous wastes for over twenty years and currently operate eleven liquid and gas incinerators in the United Kingdom and Singapore. The liquid incinerators burn, as their main streams, those solvents t...