+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nitroglycerin on central haemodynamics and VA/Q distribution early after coronary bypass surgery

, : Effects of nitroglycerin on central haemodynamics and VA/Q distribution early after coronary bypass surgery. Acta Anaesthesiologica Scandinavica 26(5): 489-497

Central haemodynamics and ventilation-perfusion (VA/Q) distribution were studied in nine patients, 21 h after coronary bypass surgery, before and during nitroglycerin (TNG) infusion. VA/Q distributions were established with the multiple inert gas elimination technique of Wagner and West. Administration of TNG resulted in a decrease in mean arterial pressure, a slight reduction in cardiac output and stroke volume and a significant increase in heart rate, possibly explained by an initial relative hypovolaemia. Pulmonary arterial pressures and filling pressures for the right and left ventricles decreased significantly. There was a significant reduction in PaO2 and an increase in venous admixture (QVA/QT) from 11.3 to 16.5% of cardiac output. This was mainly due to an initial SF6-shunt of 6.4% increasing to 12.8%. Only 3.5% of cardiac output during TNG was due to perfusion of hypoventilated areas. The mean for the control Q-distribution was 0.88 with a mean log s.d. of +/- 1.14, indicating VA/Q-mismatch and did not change significantly. The reduction of pressures in the pulmonary vascular bed was accompanied by increased ventilation of areas with high VA/Q.


PMID: 6815975

Other references

Hong, H-Won.; Lee, S-Wook.; Myung, H., 2013: Induced degradation of Tat by nucleocapsid (NC) via the proteasome pathway and its effect on HIV transcription. Human Immunodeficiency Virus type 1 (HIV-1) is a retrovirus that causes acquired immunodeficiency syndrome (AIDS). HIV-1 Tat protein upregulates transcriptional transactivation. The nucleocapsid protein NC of HIV-1 is a component of virion and pla...

Young, R.S.; Grzyb, S.E.; Crismon, L., 1977: Recurrent cerebellar dysfunction as related to chronic gasoline sniffing in an adolescent girl. Lead poisoning from "leaded" gasoline as an attendent complication. Clinical Pediatrics 16(8): 706-708

Rashdan, A.; Fogel, E.L.; McHenry, L.; Sherman, S.; Temkit, M'Hamed.; Lehman, G.A., 2004: Improved stent characteristics for prophylaxis of post-ERCP pancreatitis. Pancreatic stenting is an effective method to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in high-risk patients. This retrospective study evaluated the impact of modified stent characteristics on the rate of pos...

Segura, J.; Borja, L.; Bakke, O.M., 1976: Pharmacokinetics of sulpiride after oral and intravenous administration in the rat and the dog. The plasma concentration of sulpiride was measured in the rat and in the dog after oral and i.v. administration of the drug. In the rat only traces (less than 1 mug/ml) of sulpiride were detected in plasma after an oral dose of 100 mg/kg. The peak...

Collett, F., 1977: Commodity market outlook. Agrow marketer: 2 (12) 14-15

Banning, P. van, 1987: Further results of the Bonamia ostreae challenge tests in Dutch oyster culture. Attempts to eradicate bonamiasis in Dutch oyster culture beds (Ostrea edulis) over the period 1981-1986 are described. The average prevalence has steadily dropped, but recent larger scale studies revealed the decline was asymptotic. The results sh...

Sofronova, L.V., 1975: Characteristics of components of the fibrinolytic system in healthy children. Voprosy Okhrany Materinstva i Detstva 20(6): 17-19

Kaminskii; Lavrov; Karasyuk; Thewalt, 1994: Photoluminescence of excitons bound to the isoelectronic hydrogen-related defects B711 (1.1377 eV) in silicon. Physical Review. B, Condensed Matter 50(11): 7338-7343

Bhattacharjee, R.N.; Banerjee, B.; Akira, S.; Hande, M.Prakash., 2010: Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice. Telomeres are essential to maintain chromosomal stability. Cells derived from mice lacking telomerase RNA component (mTERC-/- mice) display elevated telomere-mediated chromosome instability. Age-dependent telomere shortening and associated chromos...

Xu, F.; Schillinger, J.A.; Aubin, M.R.; S.L.uis, M.E.; Markowitz, L.E., 2001: Sexually transmitted diseases of older persons in Washington State. Background: Sexually transmitted diseases (STDs) in persons older than 50 years are rarely studied because STDs are more common in young people. Understanding the epidemiology of STDs in older persons is important for reducing STD morbidity and fo...