+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nitroglycerin on transmural energy metabolism in the underperfused canine heart

, : Effects of nitroglycerin on transmural energy metabolism in the underperfused canine heart. Journal of Pharmacology and Experimental Therapeutics 222(3): 694-698

Effects of nitroglycerin on hemodynamics and transmural distribution of myocardial metabolites were studied at 40% of control coronary perfusion pressure induced by acute coronary stenosis in the canine heart. At 40% of coronary perfusion pressure, high energy phosphate (ATP, creatine phosphate) contents significantly diminished in all layers, especially in the inner layer. A 0.3 micrograms/kg/min intracoronary infusion of nitroglycerin showed no direct effects on energy metabolism in the underperfused myocardium. A 3 micrograms/kg/min i.v. administration of the drug under fixed coronary constriction resulted in decrease in left ventricular peak systolic pressure and systemic blood pressure, and further decrease in coronary perfusion pressure and coronary blood flow. Left ventricular end diastolic pressure and ST-segment of the epicardial ECG were elevated. High-energy phosphate contents further decreased while inorganic phosphate and lactate showed an increase. Under these conditions, release of the constriction sufficient for retention of the coronary perfusion pressure at about 40 mm Hg resulted in significant improvement of the myocardial energy metabolism without a further increase in coronary blood flow. The results suggest that when the myocardium is underperfused due to undilatable stenotic vessels with maximum autoregulation of the regional flow, it may be dangerous to administer nitroglycerin in a dose sufficient to produce a large decrease in coronary perfusion pressure.


PMID: 6809931

Other references

Passik, S.D.; Squire, P., 2009: Current risk assessment and management paradigms: snapshots in the life of the pain specialist. Opioid analgesics can be a safe and effective treatment option for patients with chronic pain, but issues surrounding their use-including side effects, tolerance, and the potential for misuse and diversion-prompt some clinicians to avoid using the...

Takakura, K., 2001: Courtship-role-reversal in the bean weevil, Bruchidius dorsalis (Coleoptera: Bruchidae): interplay between male-male competition and cryptic female choice. Females of Bruchidius dorsalis, a wild bean weevil, exhibit courtship behavior actively, whereas the males are reluctant to mate but donate a large amount of seminal fluid, which eventually enhances female fecundity. This study examined the pre- a...

Song, R.; Chen, C.; Johnston, L.J.; Kerr, B.J.; Weber, T.E.; Shurson, G.C., 2014: Effects of feeding diets containing highly peroxidized distillers dried grains with solubles and increasing vitamin E levels to wean-finish pigs on growth performance, carcass characteristics, and pork fat composition. Lipid peroxidation in animal feed can negatively affect growth performance and meat quality. Weanling pigs (n = 432; BW = 6.6 ± 0.4 kg) were used to evaluate the effects of feeding peroxidized distillers dried grains with solubles (DDGS) with 3 l...

Mahdi, R.; Madduri, A.S.; Wang, G.; Strulovici-Barel, Y.; Salit, J.; Hackett, N.R.; Crystal, R.G.; Mezey, J.G., 2013: Empirical Bayes conditional independence graphs for regulatory network recovery. Computational inference methods that make use of graphical models to extract regulatory networks from gene expression data can have difficulty reconstructing dense regions of a network, a consequence of both computational complexity and unreliable...

Anonymous, 1982: Medical education in the United States 1981-1982. JAMA 248(24): 3223-3328

Tjaij, J.K.; Raid, N.; Sutanto, A.H., 1971: Flagyl (metronidazole) in the treatment of intestinal amoebiasis (2). Journal of the Singapore Paediatric Society 13(1): 1-7

Krivokapić, Z., 2000: Rectal carcinoma--therapeutic dilemmas and possibilities. Acta Chirurgica Iugoslavica 45(2 Suppl): 9-9

Boes, A.D.; Stern, A.P.; Bernstein, M.; Hooker, J.E.; Connor, A.; Press, D.Z.; Pascual-Leone, A., 2016: H-Coil Repetitive Transcranial Magnetic Stimulation Induced Seizure in an Adult with Major Depression: A Case Report. Brain Stimulation 9(4): 632-633

Kiss, J.; Murray, D.W.; Turner-Smith, A.R.; Bulstrode, C.J., 1995: Roentgen stereophotogrammetric analysis for assessing migration of total hip replacement femoral components. A new Roentgen stereophotogrammetric analysis system, using a biplane technique, has been developed to determine the migration and rotation of total hip replacement (THR) femoral components in three dimensions. Stainless steel marker balls were in...

Simionescu-Bankston, A.; Kumar, A., 2016: Noncoding RNAs in the regulation of skeletal muscle biology in health and disease. Skeletal muscle is composed of multinucleated myofibers that arise from the fusion of myoblasts during development. Skeletal muscle is essential for various body functions such as maintaining posture, locomotion, breathing, and metabolism. Skeleta...