geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nitroglycerin, dipyridamole and propranolol on myocardial pH and pO2 during regional ischemia in the dog heart


, : Effects of nitroglycerin, dipyridamole and propranolol on myocardial pH and pO2 during regional ischemia in the dog heart. Archives Internationales de Pharmacodynamie et de Therapie 264(2): 274-289

In dogs anesthetized with pentobarbital, the left anterior descending coronary artery (LAD) was occluded so that the blood flow could be reduced to about 1/3 (partial occlusion). Before partial occlusion, myocardial pH and pO2 were 7.63 (n = 35) and 17.1 mm Hg (n = 30), respectively. Partial occlusion of the LAD decreased the pH and pO2 by 0.68 pH units and 7.4 mm Hg, respectively. In the nonischemic heart, nitroglycerin (20 micrograms/kg, i.v.) did not affect myocardial pH, although it increased the LAD flow. In the ischemic heart, however, nitroglycerin increased the myocardial pH that had been reduced by partial occlusion, without an increase in myocardial pO2. Dipyridamole (250 micrograms/kg, i.v.) did not increase pH and pO2 in both nonischemic and ischemic hearts. Propranolol (1 mg/kg, i.v.) increased both pH and pO2 of the ischemic myocardium that had been reduced by partial occlusion with a decrease in heart rate. It is concluded that propranolol and nitroglycerin restore (though incompletely) the myocardial pH that has been reduced by partial occlusion of the coronary artery, while dipyridamole does not, and that only propranolol increases the ischemic myocardial pO2.

US$29.90

PMID: 6416195


Other references

Zhou, M.; Roma, A.; Magi-Galluzzi, C., 2005: The usefulness of immunohistochemical markers in the differential diagnosis of renal neoplasms. Histologic subtyping of RCC has been shown to be of prognostic value; therefore, it is important to classify malignant epithelial tumors of the kidney correctly and also to differentiate them from benign ones. Overlapping morphologic features of r...

Elahi, E.; Meltzer, M.A.; Friedman, A.H.; Som, P.M., 2003: Primary orbital angiomatous meningioma. Archives of Ophthalmology 121(1): 124-127

Haynes, C.V.; Damon, P.E.; Grey, D.C., 1966: Arizona radiocarbon dates 6, A-538 Turtle. Radiocarbon, 8: 5

Suarez, A., 1974: Incorporation of phosphate, acetate, and glycerol into phospholipids of Ceratitiscapitata larvae. Turnover of labelled phospholipids during metamorphosis. Insect Biochem(3): 395-400

Hirano S., 1980: Syntheses of Fe(II) bearing oxide crystals under hydrothermal conditions. Kobutsugaku Zasshi = Journal of the Mineralogical Society of Japan: pecial issue No. 2, Pages 161-171. 1980.

Metcalf, T.G.; Amell, A.R.; Slanetz, L.W.; Brown, E.A., 1960: Studies of the dispersion of emulsified extracts by means of incorporated radioisotopes. Annals of Allergy 18: 983-989

To, T.H.M.; Agar, M.; Shelby-James, T.; Abernethy, A.P.; Doogue, M.; Rowett, D.; Ko, D.; Currow, D.C., 2013: Off-label prescribing in palliative care - a cross-sectional national survey of palliative medicine doctors. Regulatory bodies including the European Medicines Agency register medications (formulation, route of administration) for specific clinical indications. Once registered, prescription is at clinicians’ discretion. Off-label use is beyond the...

Mortier, E.; Quemener, A.; Vusio, P.; Lorenzen, I.; Boublik, Y.; Grotzinger, J.; Plet, A.; Jacques, Y., 2006: Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma - Hyperagonist IL-15 center dot IL-15R alpha fusion proteins. Interleukin-15 (IL-15) is crucial for the generation of multiple lymphocyte subsets (natural killer (NK), NK-T cells, and memory CD8 T cells), and transpresentation of IL-15 by monocytes and dendritic cells has been suggested to be the dominant ac...

Kogan, R.B.; Shishkova, V.F., 1962: Rationalization of medical service for school children. Our proposal. Sovetskoe Zdravookhranenie 21(5): 43-48

Nesslany, F., 2016: The current limitations of in vitro genotoxicity testing and their relevance to the in vivo situation. NlmCategory="UNASSIGNED">The standard regulatory core battery of genotoxicity tests generally includes 2 or 3 validated tests with at least one in vitro test in bacteria and one in vitro test on cell cultures. However, limitations i...