+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nitroprusside and D 600 on norepinephrine- and KCl-stimulated Ca++ activation and contraction systems in canine renal vein as compared to canine renal artery

, : Effects of nitroprusside and D 600 on norepinephrine- and KCl-stimulated Ca++ activation and contraction systems in canine renal vein as compared to canine renal artery. Journal of Cardiovascular Pharmacology 6(5): 762-771

The effects of nitroprusside (NP) and D 600 on norepinephrine (NE)- and KCl-induced maximal contractions and unstimulated 45Ca uptake and efflux were delineated in canine renal vein (CRV) and compared with results in renal artery. In CRV, but not in renal artery, NE-induced contractions are usually associated with rhythmic oscillations in developed tension. Corresponding KCl-induced contractions are not associated with rhythmic activity and are depressed by 57% in the presence of phentolamine (PA). The calcium channel blocker, D 600, rapidly and extensively relaxed NE-induced contractions (86%) in CRV, but slowly and moderately relaxed similar responses in artery (46%). PA-resistant, KCl-induced contractions were equally sensitive to the relaxant effects of D 600 in CRV (73%) or artery (72%), but the rate of relaxation was much more rapid in CRV. Prior exposure to D 600 inhibited KCl-induced contractions in both CRV and artery (99 versus 91%, respectively). Similar prior treatment reduced NE-induced contractions (60%) in CRV, and prevented the development of any NE-dependent rhythmic activity. In renal artery, NE-induced contractions were unaffected by prior D 600 exposure. NP relaxed KCl-induced contractions 32% in the presence of PA in CRV, but had little effect on KCl-induced responses in artery (6%). Prior exposure to NP inhibited KCl-induced contractions 60-67% in CRV, which is approximately twice the inhibition seen in artery (31%). Relaxation of NE-induced contractions with NP in CRV and renal artery are (43% and 38%, respectively) approximately equal. In renal artery, responses to NE are less sensitive (1.6-fold) to prior NP exposure than in CRV. Prior exposure to NP or to NP plus D 600 reduced NE-induced contractions in CRV 37% and 96%, respectively. NP and D 600 were without effect on unstimulated 45Ca uptake in CRV. In CRV, D 600 had no effect on 45Ca efflux into a O-Ca++ solution, whereas NP decreased the rate of 45Ca efflux in a maintained manner. Thus, NP and D 600 appear to interfere with differing components of Ca++ entry and Ca++ release in CRV. However, these components are less readily differentiated and more interdependent than similar, well-defined and characterized components in arterial smooth muscle, and appear to be convergent.


PMID: 6209478

Other references

Telyatnikova, T.V.; Lazaricheva, I.V., 1989: Effect of the method of adding the aluminium-containing compound on the property of ammonium oxidation catalysts. The effect of methods of adding aluminium compounds on the properties of ammonia oxidation catalysts was studied. In order to obtain a selective and sufficiently strong catalyst, a highly acidic environment is needed in the preparation process. So...

Ivanov, V.A.; Bychvarov, I.V.; Aksiuk, M.A., 1988: Paravalvular fistulas following mitral prosthesis. Khirurgiia: 49-52

Wood, B.D., 2014: A modified Fuchs view solution. Radiologic Technology 85(2): 213-214

Miller, D.D.; Warshaw, E.M., 2007: Adverse cutaneous reactions to antimicrobials in patients with human immunodeficiency virus infection. Adverse reactions to medication are significant contributors to morbidity and mortality in patients with human immunodeficiency virus (HIV) infection. Cutaneous events not only constitute a significant portion of these reactions, they may also her...

Knudsen, E.C.; Seljeflot, I.; Abdelnoor, M.; Eritsland, J.; Mangschau, A.; Müller, C.; Arnesen, H.; Andersen, G.Ø., 2012: Elevated levels of PAI-1 activity and t-PA antigen are associated with newly diagnosed abnormal glucose regulation in patients with ST-elevation myocardial infarction. Both Type 2 diabetes and cardiovascular disease have been associated with enhanced coagulation and suppressed fibrinolysis. To investigate a possible relationship between selected hemostatic variables and abnormal glucose regulation (AGR) in patie...

Zhang, Q.; Li, Y.; Howard, T.H., 1997: Specific leufactin domains are required for F-actin bundling and hair formation characteristic of the human motility defect-NAD 47/89. Blood 90(10 SUPPL 1 PART 1): 437A, Nov 15

Jendrasiak G.L.; Eghbal M., 1985: The structure of iodolipid phospholipid aggregates for computed tomographic hepatic imaging. Biophysical Journal 47(2 PART 2): 114A

Freeman, P.; Bayer, S.Norman., 2017: Spencer Norman Bayer. Spencer Bayer cared about people; his legacy is one of hard work and high moral and ethical standards.

Duxbury, R., 2000: Fruit and vegetables. This paper explores the organic fruits and vegetables sector in the UK. It discusses: the major issues confronting growers, producers and certifiers in the expansion of the organic fresh produce sector; growing systems; the current market situatio...

Gozes, I., 2011: Microtubules, schizophrenia and cognitive behavior: preclinical development of davunetide (NAP) as a peptide-drug candidate. NAP (davunetide) is an active fragment of activity-dependent neuroprotective protein (ADNP). ADNP and the homologous protein ADNP2 provide cell protection. ADNP is essential for brain formation, proper development and neuronal plasticity, all repo...