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Effects of nitroprusside on pancreatic juice secretion in the blood-perfused canine pancreas

, : Effects of nitroprusside on pancreatic juice secretion in the blood-perfused canine pancreas. European Journal of Pharmacology 79(1-2): 53-60

The effects of nitroprusside on the secretion of pancreatic juice were investigated in preparations of isolated and blood-perfused canine pancreas. Nitroprusside (10-30 micrograms/kg) injected intravenously elicited a dose-dependent increase in pancreatic secretion accompanied by a decrease in blood pressure. Intra-arterial administration of nitroprusside (3-300 micrograms) into the perfused pancreas also elicited an increased secretion in preparations of both constant pressure and constant flow perfusion system. The results suggest that nitroprusside-induced pancreatic secretion may not result from the peripheral vasodilatation caused by nitroprusside. The effect of 100 micrograms of intra-arterial nitroprusside corresponded roughly to that of 0.1 units of secretin or 0.3 units of pancreozymin. Nitroprusside-induced secretion was inhibited by the infusion of ethacrynic acid (1 mg/min), but was not modified by phentolamine, propranolol, atropine, haloperidol, tetrodotoxin and metiamide. Nitroprusside produced a dose-dependent increase in the bicarbonate and protein concentrations in the juice, but had little effect on chloride concentration. This action was different from that of secretin or pancreozymin. It is concluded that nitroprusside may produce an increase in pancreatic secretion by acting directly on pancreatic cells, and that this action may be mediated at least in part through the increase of intracellular cyclic GMP concentration.


PMID: 7084309

Other references

Lavoipierre, M.M., 1970: A note on the sarcoptid mites of Primates. Journal of Medical Entomology 7(3): 376-380

Liu, B.; Jiang, Y.; Dong, T.; Zhao, M.; Wu, J.; Li, L.; Chu, Y.; She, S.; Zhao, H.; Hoffman, R.M.; Jia, L., 2016: Blockage of autophagy pathway enhances Salmonella tumor-targeting. Previous studies have shown that strains of Salmonella typhimurium specifically target tumors in mouse models of cancer. In this study, we report that tumor-targeting Salmonella typhimurium A1-R (A1-R) or VNP20009 induced autophagy in human cancer...

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Jimenez-Castano, L.V.llamiel, M.M.rtin-Alvarez, P.; Olano, A.L.pez-Fandino, R., 2005: Effect of the dry-heating conditions on the glycosylation of b-lactoglobulin with dextran through the Maillard reaction. Food hydrocolloids t 19(5): 831-837

Massou, S.; Puech, V.; Talmont, F.; Demange, P.; Lindley, N.D.; Tropis, M.; Milon, A., 1999: Heterologous expression of a deuterated membrane-integrated receptor and partial deuteration in methylotrophic yeasts. Methylotrophic yeast has previously been shown to be an excellent system for the cost-effective production of perdeuterated biomass and for the heterologous expression of membrane receptors. A protocol for the expression of 85% deuterated, functio...

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Malten, H., 1955: Problems of saltless diet; from the Institute for Circulatory and Metabolic Diseases in Baden-Baden. Hippokrates 26(22): 677-681

Horner R.D.; Moudrianakis E.N., 1986: The effect of permeant amine buffers on photophosphorylation and postillumination in chloroplasts. Federation Proceedings 45(6): 1892

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