geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nomifensine and desipramine on the sequelae of intracerebrally-injected 6-OHDA and 5,6-DHT


, : Effects of nomifensine and desipramine on the sequelae of intracerebrally-injected 6-OHDA and 5,6-DHT. Pharmacology, Biochemistry, and Behavior 13(6): 915-917

Pretreatment with either nomifensine or desipramine (15 mg/kg) attenuated the depletion of forebrain noradrenaline induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. Neither pretreatment influenced the depletions of striatal dopamine induced by medial forebrain bundle lesions with 6-hydroxydopamine or 5,6-dihydroxytryptamine, or contralateral rotational responses to apomorphine in the 6-hydroxydopamine-lesioned animals. Pretreatment with nomifensine attenuated the depletion of striatal dopamine induced by intrastriatal injections of 6-hydroxydopamine, consistent with inhibition of dopamine uptake in vivo. Nomifensine may differently influence distinct axonal and terminal uptake mechanisms for dopamine.

US$29.90

PMID: 7193877


Other references

Yiangou Y.; Christofides N.D.; Blank M.A.; Yanaihara N.; Bishop A.; Tatemoto K.; Polak J.M.; Bloom S.K., 1984: Non equimolar levels of peptide histidine isoleucine and vasoactive intestinal peptide in the stomach explained by the presence of a big peptide histidine isoleucine like molecule. Gut 25(10): A1159

Morselli, T.B.G.A.; Cruz, L.E.C. da; Pocai, D.; Pich, A.H., 1997: Effect of different wastes on the comportment of Eisenia foetida in hot season: I. Emergence. Five solid wastes: ruminal contents, coffee dregs, earthworm humus, mate (Ilex paraguariensis) and cattle manure (fresh, semi-fresh and decomposed), were utilized to evaluate the emergence of Eisenia foetida in two seasons: spring and summer. Each...

Fisher, E.J.; McLennan, S.V.; Yue, D.K.; Turtle, J.R., 1997: High glucose reduces generation of plasmin activity by mesangial cells. Mesangium enlargement is a central feature of diabetic nephropathy and almost certainly plays a pathogenic role in this condition. Previous studies have shown that mesangium degradation is reduced in a high glucose mileau. Plasmin has been shown t...

Polskaia, N.; Richer, N.; Dionne, E.; Lajoie, Y., 2015: Continuous cognitive task promotes greater postural stability than an internal or external focus of attention. Research has demonstrated clear advantages of using an external focus of attention in postural control tasks, presumably since it allows a more automatic control of posture to emerge. However, the influence of cognitive tasks on postural stability...

Chaplin, A.J., 1974: Some observations on the demonstration of calcium oxalate in tissue sections. Stain Technology 49(3): 165-173

Wei, J.; Ramchand, C.N.; Hemmings, G.P., 1998: TaqI polymorphic sites at the human dopamine beta-hydroxylase gene possible associated with biochemical alterations of the catecholamine pathway in schizophrenia. Two parts of the dopamine beta-hydroxylase (DBH) gene, one a 7.5-kb single copy fragment (F1) spanning the 5'-flanking region to exon 3 and the second a 9.0-kb single copy fragment (F2) spanning exon 3 to exon 7, were amplified by a long PCR...

Uozumi, T.; Mori, S.; Watanabe, M.; Takimoto, N.; Mogami, H., 1976: Endocrinological evaluation of sellar and suprasellar tumor cases (the seventh report)--endcrinological study on four cases of pituitary adenoma with intratumoral hemorrhage. Four cases of pituitary adenoma with intratumoral hemorrhage were studied endocrinologically. 1) It would be suggested that ACTH and TSH secretion of these cases was strongly impaired but LH, FSH and PRL secretion was fairly preserved immediately...

Day, A.J.; Gee, J.M.; DuPont, M.Susan.; Johnson, I.T.; Williamson, G., 2003: Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Two hypotheses on absorption mechanisms of flavonoid glucosides across the small intestine have been proposed: active uptake of the quercetin glucoside by the sodium-dependent glucose transporter (SGLT1) with subsequent deglycosylation within the...

Rauther, Max., 1909: Das Kopulationsorgan von Clinus. Jena Denkschriften der Med Gesellschaft, 15 467-476

Prossor, T.M., 1951: Malignant disease of the testis with special reference to radiotherapy. British Journal of Surgery 38(152): 473-481