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Effects of nomifensine and desipramine on the sequelae of intracerebrally-injected 6-OHDA and 5,6-DHT

, : Effects of nomifensine and desipramine on the sequelae of intracerebrally-injected 6-OHDA and 5,6-DHT. Pharmacology, Biochemistry, and Behavior 13(6): 915-917

Pretreatment with either nomifensine or desipramine (15 mg/kg) attenuated the depletion of forebrain noradrenaline induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. Neither pretreatment influenced the depletions of striatal dopamine induced by medial forebrain bundle lesions with 6-hydroxydopamine or 5,6-dihydroxytryptamine, or contralateral rotational responses to apomorphine in the 6-hydroxydopamine-lesioned animals. Pretreatment with nomifensine attenuated the depletion of striatal dopamine induced by intrastriatal injections of 6-hydroxydopamine, consistent with inhibition of dopamine uptake in vivo. Nomifensine may differently influence distinct axonal and terminal uptake mechanisms for dopamine.


PMID: 7193877

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