+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nomifensine and its metabolites on dihydropteridine reductase

, : Effects of nomifensine and its metabolites on dihydropteridine reductase. Journal of Pharmacy and Pharmacology 36(6): 411-413

Nomifensine and three of its metabolites were studied as potential inhibitors of dihydropteridine reductase. Purified enzyme preparations from human liver and the P2 fraction of rat striatal synaptosomes were used as enzyme sources. Nomifensine and its 3'-hydroxyl derivative inhibit this enzyme from both sources at 1.3 to 3.5 X 10(-4)M (150 values). 4'-Hydroxylated nomifensines, however, non-competitively inhibited this enzyme with Ki values of 2.8 to 4.4 X 10(-5)M. Dihydropteridine reductase regenerates tetrahydrobiopterin, the required cofactor for the hydroxylation of tyrosine and tryptophan, from quinonoid dihydrobiopterin. Inhibition of this enzyme could reduce the availability of the biopterin cofactor for the synthesis of dopamine and 5-hydroxytryptamine.


PMID: 6146678

Other references

Kennedy, J.Randall., 2015: Attenuating a sickle cell crisis with annexin V. A sickle cell crisis is a painful and dangerous condition that defies effective treatment but fortunately it usually terminates spontaneously and patients spend far more time crisis free than in its painful throes. This suggests that an unstable p...

Bauch, H.A.; Erlenkeuser, H.; Grootes, P.M.; Jouzel, J., 1996: Implications of stratigraphic and paleoclimatic records of the last interglaciation from the Nordic seas. Climatic reconstruction of glacial to interglacial episodes from oxygen isotopes in sediment cores from the Nordic seas is complicated by strong local meltwater contributions to the oxygen isotope changes. Combination of benthic and planktic foram...

Funaki, B., 2007: Prophylactic angioplasty of failing hemodialysis shunts. Seminars in Interventional Radiology 24(1): 130-133

Arian, E., 1959: Three current problems of contemporary mental hygiene: old age, automation, epilepsy. Minerva Medica 50(10): 299-305

Oyidi, O., 1977: Studies on the effects of Propoxur and Dioxacarb on Zonocerus variegatus (Linnaeus) and Phymateus cinctus (Fab.) (Orthoptera). Samaru agricultural newsletter: 19 (1) 3-7

Wenger, M.; Markwalder, T-Marc., 2016: Heterotopic ossification associated with myelopathy following cervical disc prosthesis implantation. This case report presents a 37-year-old man with clinical signs of myelopathy almost 9 years after implantation of a Bryan disc prosthesis (Medtronic Sofamor Danek, Memphis, TN, USA) for C5/C6 soft disc herniation. As demonstrated on MRI and CT sc...

Chung YongMo; Kim JeongBu; Kwon OhChang, 2004: A new high-yielding bi-colored gerbera cut flower cultivar, Sunny. Gerbera hybrida [Gerbera] cv. Sunny was developed from a cross between Princessa and Tamara, followed by seedling and line selections at the Flower Breeding Research Institute, Gyeongnam Agricultural Research and Extension Services, Korea, in 1999...

Chellemi, D.O.; Ajwa, H.A.; Sullivan, D.A.; Alessandro, R.; Gilreath, J.P.; Yates, S.R., 2011: Soil fate of agricultural fumigants in raised-bed, plasticulture systems in the southeastern United States. Soil concentrations and degradation rates of methyl isothio-cyanate (MITC), chloropicrin (CP), 1,3-dichloropropene (1,3-D), and dimethyl disulfide (DMDS) were determined under fumigant application scenarios representative of commercial raised bed,...

Ziemssen, T.; D.S.efano, N.; Pia Sormani, M.; Van Wijmeersch, B.; Wiendl, H.; Kieseier, B.C., 2016: Optimizing therapy early in multiple sclerosis: An evidence-based view. Therapies that target the underlying pathology of multiple sclerosis (MS), including focal and diffuse damage, may improve long-term disease control. Focal damage (inflammatory lesions) manifests clinically mainly as relapses, whereas diffuse dama...

Boesch Donald F., 2002: Challenges and opportunities for science in reducing nutrient over-enrichment of coastal ecosystems. Nutrient over-enrichment has resulted in major changes in the coastal ecosystems of developed nations in Europe, North America, Asia, and Oceania, mostly taking place over the narrow period of 1960 to 1980. Many estuaries and embayments are affect...