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Effects of non-linear flow and spatial orientation on technetium-99m hexamethylpropylene amine oxime single-photon emission tomography

, : Effects of non-linear flow and spatial orientation on technetium-99m hexamethylpropylene amine oxime single-photon emission tomography. European Journal of Nuclear Medicine 22(9): 1009-1016

The effects of two post-acquisition corrections on the visual and quantitative analysis of technetium-99m hexamethylpropylene amine oxime (HMPAO) single-photon emission tomography (SPET) were determined. The corrections were for: (1) the improper spatial orientation of the patient data sets, and (2) the non-linear uptake of HMPAO across the blood-brain barrier. Reorienting the SPET image data sets removed observers' uncertainty in assessment caused by suspected head tilt; however, it increased their uncertainty due to perceived subtle perfusion deficits. Applying the correction to compensate for the decrease in uptake of HMPAO in high-flow regions resulted in an increase in the number of positive assessments. In a study involving 30 patient studies, intra-observer reliability increased from 62% to 83% (average of two observers) after applying both of the corrections, while inter-observer reliability improved from 62% to 81%. Quantitative methods of analysing the images are also affected by the corrections. In an ROI-based classification scheme, the quantitative assessments of more than one-half of the images are affected by the two corrections. These results need to be considered when comparing both quantitative and visual results from different studies in which the corrections may or may not have been applied.


PMID: 7588937

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Sumner, S.C.J.; Williams, C.C.; Snyder, R.W.; Krol, W.L.; Asgharian, B.; Fennell, T.R., 2003: Acrylamide: a comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure. Acrylamide (AM), which is used to manufacture polymers, is carcinogenic and a reproductive and neurological toxicant. The objective of this study was to compare the metabolism of AM administered orally (po), dermally, intraperitoneally (ip), or by...

Martin, D.L., 1983: Technology assessment: an international perspective. Dimensions in Health Service 60(4): 33-33

Priluck, I.A.; Robertson, D.M.; Buettner, H., 1981: Acute posterior multifocal placoid pigment epitheliopathy. Urinary findings. Archives of Ophthalmology 99(9): 1560-1562

Hanson, H.; Haschen, R.J., 1958: Characteristics of the aminopeptidases of the blood serum. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 310(3-6): 213-220

Jeong, S-Hee.; Kang, D.; Lim, M-Woon.; Kang, C.Soo.; Sung, H.Jung., 2010: Risk assessment of growth hormones and antimicrobial residues in meat. Growth promoters including hormonal substances and antibiotics are used legally and illegally in food producing animals for the growth promotion of livestock animals. Hormonal substances still under debate in terms of their human health impacts ar...

Giarola, A.; Ballerio, L., 1950: Present status of hormonology. I. Is antigonadotropin produced by chorionic gonadotropin treatment?. Annali di Ostetricia E Ginecologia 72(8): 926-940

Govender, P.; Byrne, A.; Lyburn, I.D.; Torreggiani, W.C., 2006: Generalized skull vault thickening in association with a large arteriovenous malformation. Generalized thickening of the skull is unusual but has a number of recognized associations such as chronic severe anaemia, Paget disease and phenytoin therapy. We report a case of generalized skull vault thickening seen in association with a large...

Hong M W., 1972: The influence of hyang yak myeong korean idu herbal common names upon japanese herbals. Korean Journal of Pharmacognosy 3(1): 1-10

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