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Effects of nonachloropredioxin and other hydroxychlorodiphenyl ethers on biological membranes

, : Effects of nonachloropredioxin and other hydroxychlorodiphenyl ethers on biological membranes. Journal of Toxicology and Environmental Health 6(1): 11-25

Effects of the chlorophenolic compounds.sbd.hydroxynonachlorodiphenyl ethers (HO-Cl9-DPE), contaminants (1-5%) of commercial pentachlorophenol preparations; 2-hydroxy-2',4,4'-trichlorodiphenyl ether (HO-Cl3-DPE); and pure and technical pentachlorophenol (PCP [a pesticide]).sbd.on biological membranes were studied with the human erythrocyte membrane as a model. The HO-Cl9-DPE are very potent hemolytic agents. The order of activity, based on the concentration of compound producing 50% hemolysis (shown in parentheses), under standard conditions is: 2-HO-Cl9-DPE (3.8 .mu.M) > 3-HO-Cl9-DPE (7.1 .mu.M) > 4-HO-Cl9-DPE (8.4 .mu.M) > 2-HO-Cl3-DPE (68 .mu.M) > technical PCP (360 .mu.M) > pure PCP (950 .mu.M). Among the HO-CLX-DPE, the hemolytic potency varies with the degree of chlorination and, to some extent, with the position of the hydroxyl group. At lower concentrations, HO-ClX-DPE protect the erythrocyte against hypotonic hemolysis; these compounds are effective at much lower concentrations than is pure PCP. In the range of concentrations required for maximum protection against hypotonic hemolysis, the chlorophenolic compounds induce the formation of erythrocyte morphological forms different from the normal discocyte. The chlorophenolic compounds induce the prelytic efflux of K+, from intact erythrocytes in an order of efficacy that parallels their hemolytic effect. Hydroxychlorodiphenyl ethers are membrane-active chemicals, capable of directly altering properties of biological membranes.


PMID: 7381964

DOI: 10.1080/15287398009529827

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