+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity

, : Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity. Agents and Actions 12(4): 516-520

In the present study, the effects of acetylsalicylic acid, diclofenac, ibuprofen, indomethacin, naproxen, phenylbutazone, proquazone, fluproquazone (RF 46-790 N), sulindac (sulfoxide and sulfide forms) and tolfenamic acid were compared on rat gastric mucosal cyclic nucleotide phosphodiesterases (PDEs). Some of the drugs inhibited PDEs effectively, the Ki values being clearly lower than those of theophylline. Mostly the type of inhibition was apparently competitive. Acetylsalicylic acid and ibuprofen were ineffective. No unambiguous correlation between the inhibition of mucosal PDEs and clinically observed gastric irritation was found. However, the inhibition of PDEs may modulate gastric side-effects of NSAIDs.


PMID: 6295110

Other references

Malangu, N.; Legothoane, A., 2013: Analysis of occupational infections among health care workers in Limpopo province of South Africa. Occupational infections particularly hospital-acquired infections (HAIs) are a serious problem in the healthcare industry worldwide. This study purported to investigate their prevalence and risk factors among healthcare workers from Limpopo provin...

Engberg I., 1969: Is picro toxin a blocker of the post synaptic inhibition induced by gamma amino butyric acid. Pfluegers Archiv European Journal Of Physiology-2: 121

Atsumi, A.; Ishizu, T.; Kameda, Y.; Yamamoto, M.; Harimura, Y.; Machino-Ohtsuka, T.; Kawamura, R.; Enomoto, M.; Seo, Y.; Aonuma, K., 2014: Application of 3-dimensional speckle tracking imaging to the assessment of right ventricular regional deformation. The aim of this study was to carry out 3-dimensional speckle tracking imaging (3DSTI) of the right ventricle (RV) and evaluate RV regional wall deformation. 3DSTI of the RV was performed in 35 normal subjects, 8 patients with arrhythmogenic right...

Bober, A.F.; Nosenko, Y.M., 1999: Genetical nature of nectar productivity trait of alfalfa plants. Self fertile lines of alfalfa [lucerne] with high and low content of nectar were isolated. The genetic nature of nectar productivity was studied using the Jinks-Hayman method in a diallel scheme. This trait has a complex nature and was controlled...

Wieland P., 1986: Hydrological tasks along a tidal coast. Wasser und Boden 38(12): 616-620

Louisse, J.; Verwei, M.; Woutersen, R.A.; Blaauboer, B.J.; Rietjens, I.M.C.M., 2012: Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation. Reliable in vitro and in silico assays as alternatives for in vivo developmental toxicity studies are urgently needed, for the replacement, reduction and refinement (3Rs) of animal use in toxicological research. Therefore, relevant biomarkers for...

Tuschen Caffier, B.; Vogele, C.; Bracht, S.; Hilbert, A., 2003: Psychological responses to body shape exposure in patients with bulimia nervosa. One of the unresolved issues regarding research on bulimia nervosa concerns the question as to how patients diagnosed with bulimia nervosa respond to body image exposure. In addition, it remains unclear whether there are differential responses ass...

Stockmal G.S., 1990: The stratigraphy of the Alberta foreland basin; an interpretation in terms of Cordilleran tectonics. Atlantic Geology 26(2): 196

Kee, R.D.; Sinclair, J.G.; Sangiah, S.; Wells, J.N.; Yim, G.K., 1975: Antagonism by diphenylaminoethanol of GABA-induced inhibition of Deiters neurones. Neuropharmacology 14(11): 785-790

Mitchell J.C., 1981: Industrial aspects of 112 cases of allergic contact dermatitis from frullania in british columbia canada during a 10 year period. Contact Dermatitis: 268-269