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Effects of nonsteroidal antiinflammatory drugs on the proton exchange reaction between octanol and water: its correlation with their inhibitions of inflammation and prostaglandin synthesis

, : Effects of nonsteroidal antiinflammatory drugs on the proton exchange reaction between octanol and water: its correlation with their inhibitions of inflammation and prostaglandin synthesis. Biochemical and Biophysical Research Communications 113(3): 745-750

Effect of various antiinflammatory drugs on proton exchange between octanol OH and water after partition equilibrium between octanol and water at pH 7.4 was examined. These drugs accelerated the proton exchange reaction to different extents. The rate constant of the proton exchange induced by the drugs was well correlated with their biological potencies in inhibiting Carrageenan-induced edema and prostaglandin synthesis, suggesting that proton or electron movement in an apolar environment is very important for exhibition of these biological effects.


PMID: 6307302

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Wadelius, C.; Lagerkvist, A.; Molin, A.K.; Larsson, A.; von Döbeln, U.; Pettersson, U., 1993: Galactosemia caused by a point mutation that activates cryptic donor splice site in the galactose-1-phosphate uridyltransferase gene. NM23 is a candidate tumor suppressor protein and has recently been identified as an NDP kinase. The expression of NM23 is inversely related to the metastatic potential of tumor cells. Two NM23 genes, NME1 and NME2, that code for the A and B chains...

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