+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of noradrenergic and serotonergic neurons on blood pressure, heart rate and baroreceptor-heart rate reflex of the conscious rabbit

, : Effects of noradrenergic and serotonergic neurons on blood pressure, heart rate and baroreceptor-heart rate reflex of the conscious rabbit. Journal of the Autonomic Nervous System 3(2-4): 511-523

The acute and chronic effects of intracisternal (i.c.) 6-hydroxydopamine (6-OHDA) and 5,6-dihydroxytryptamine (5,6-DHT) on mean arterial pressure (MAP), heart rate, and baroreceptor-heart rate reflex properties were examined in conscious rabbits. The reflex was studied by deriving MAP-heart period (HP, pulse interval) curves. The acute effects occurring over the first few hours were due to release of transmitter (noradrenaline after 6-OHDA; serotonin after 5,6-DHT) from specific synaptic sites; the changes on day 14 were due to destruction of specific neurons. Noradrenergic bulbar neurons facilitate vagal heart rate motoneurons and serotonergic neurons have an inhibitory effect. Noradrenergic bulbospinal pathways have a depressor effect on MAP and serotonergic bulbospinal activity increases MAP. These effects on heart rate and MAP were mediated through independent parallel pathways. The acute circulatory changes due to each neurotoxin also included a long latency pressor component, which was mediated through a pathway where a serotonergic neuron was in series with a noradrenergic neuron which sends fibers to a suprapontine pressor site. There were no chronic changes in resting MAP or heart rate, but chronic changes in reflex HP range and gain were opposite to the acute effects of transmitter release. These findings indicate that noradrenergic and serotonergic neurons normally participate in the central baroreceptor-heart rate reflex pathways of the intact animal.


PMID: 7276444

Other references

Sipahi, T.; Pocan, H.; Akar, N., 2006: Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis. Several genetic polymorphisms have been identified in patients with sepsis and severe sepsis, such as the tumor necrosis factor-alpha (TNF-alpha) and TNF-beta genes, the interleukin-1 (IL-1) family, the IL-6, the IL-10, the CD-14, the Toll-like re...

Echternkamp S.E.; Lunstra D.D., 1982: Relationship between luteinizing hormone and testicular development in progesterone implanted pre pubertal rams. Biology of Reproduction 26(SUPPL 1): 128A

E.G.oumari, M.Y.; Tantau, H.J.; Serrano, J., 2005: Non-linear constrained MPC: real-time implementation of greenhouse air temperature control. This work describes the application of model predictive control (MPC) for temperature regulation in agricultural processes. The main objective is to achieve temperature control of a greenhouse built in the Institute for Horticultural and Agricultu...

Urbach, E.; Giovannoni, S.J., 1998: Molecular analysis of population structure and productivity estimates for bacterioplankton communities in Crater Lake, Oregon. Abstracts of the General Meeting of the American Society for Microbiology 98: 391

Lopez Meyer, M.; Nessler, C.L., 1995: Expression of a Camptotheca acuminata tryptophan decarboxylase gene during seedling development. Plant Physiology (Rockville) 108(2 SUPPL ): 49

Johnston D.H.; Toksoz M.N., 1977: Internal structure and properties of Mars. Theoretical physical models of the Martia interior are presented in the light of new and revised data and constraints. These models include thermal evolution, densities, and seismic wave velocities. The interior of Mars appears to be Earth-like in...

Kauert, Gerold, 2002: Drogenkonsum und Fahruntuechtigkeit aus medizinisch-toxikologischer Sicht: Gibt es jetzt Grenzwerte zur absoluten Fahruntuechtigkeit?. From the legal medical point of view, the establishment of another workshop dealing with illicit drugs in road traffic on the 40th 'Deutscher Verkehrsgerichtstag' is indeed welcome. In 3 areas, advances made since the 31st 'Deutsche...

Nüdling, S.; Kahner-Gröne, S.; Köneke, D.; Marggraf, K.; Palissa, H., 2011: Adjustment of antihypertensive therapy to a generic eprosartan preparation. Results of a non-interventional study. Mmw Fortschritte der Medizin 152 Suppl 3: 96-101

Dawson, J.; Govardhan, S.; Dar, K.A.; Bharat, R., 2007: Effect of different weed management practices on growth and yield of fieldpea (Pisum sativum L.) var. rachna. A field experiment was conducted during rabi season of 2000-2001 to identify the weed problems in pea. Pre-emergence application Fluchloralin at 1.0 kg ha(-1) + hand weeding at 30 DAS significantly reduced the total weed density and dry weight. T...

Lai Xingling; Zhang Xiankang; Zheng Xuyao, 1997: 3-D structural reconstruction of Moho in the Tangshan earthquake area by using inversion of curved interface. A method for inverting 3-D curved interface and layer velocity by using travel time of reflected waves is studied. Each interface is described with sectional, incomplete cubic polynomial. A fast 3-D ray tracing method is used in forward problem, a...