geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of norepinephrine and alpha-block on O2 uptake and blood flow in dog hindlimb


, : Effects of norepinephrine and alpha-block on O2 uptake and blood flow in dog hindlimb. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 51(5): 1245-1250

Norepinephrine (NE) may increase skeletal muscle O2 demand at the same time that it restricts O2 transport by vasoconstriction. We prevented vasoconstriction with 3.0 mg/kg phenoxybenzamine (alpha-Bl) in 10 anesthetized, paralyzed dogs ventilated at constant rate. Hindlimb and whole-body O2 uptake (VO2) and blood flow were measured for a 20-min control period, 20 min of NE infusion at 1 micrograms . kg-1 . min-1 either intravenously (iv) or intra-arterially (ia), and 20 min of recovery. The sequence was repeated for the other route of infusion. A second group of 10 without alpha-Bl was treated the same. Cardiac output increased with both ia and iv infusions in the no-block group and was unchanged in the alpha-Bl group. Limb blood flow increased 25% during the first 5 min of iv but decreased 40% with ia infusion in the no-block group. Whole-body VO2 was significantly increased 9% in both groups by both routes of NE. Limb VO2 was significantly decreased in the no-block group at 5 min of NE infusion iv when limb blood flow was increased. Limb VO2 did not change significantly in the alpha-Bl group with NE by either route. Hindlimb skeletal muscle did not participate in or contribute to the calorigenic effect of NE on the whole body, and that lack of effect was not due to any effect of NE on rate or distribution of blood flow in the limb.

US$29.90

PMID: 6117544


Other references

McEvoy, L.K.; Kritz-Silverstein, D.; Barrett-Connor, E.; Bergstrom, J.; Laughlin, G.A., 2013: Changes in alcohol intake and their relationship with health status over a 24-year follow-up period in community-dwelling older adults. To determine whether alcohol use changes over time in older adults and whether alcohol intake is associated with common chronic diseases. Twenty-four-year longitudinal study. Southern California community. One thousand seventy-six members of the R...

Cuff, K.; Hurley, J.; Mestelman, S.; Muller, A.; Nuscheler, R., 2012: Public and private health-care financing with alternate public rationing rules. We develop a model to analyze parallel public and private health-care financing under two alternative public sector rationing rules: needs-based rationing and random rationing. Individuals vary in income and severity of illness. There is a limited...

Molinari, G.; Sardanelli, F.; Ottonello, C.; Renzetti, P.; Basso, M.; Caponnetto, S., 1992: Magnetic resonance tomography compared to computed tomography in the intracardiac spread of hepatocarcinoma. A cirrhotic patient with inferior cava and right atrium-ventricular invasion by hepatic tumor was studied with transthoracic echocardiography (TTE), computerized tomography (CT) before and after contrast agent bolus iv, ECG-gated magnetic resonanc...

Szarek-Gwiazda, Ewa, 1999: Heavy metal contents in stone loach Noemacheilus barbatulus (L.) (Cobitidae) living in the river above and below dam reservoir (Dobczyce reservoir, southern Poland). The concentrations of Cd, Pb, Cu, Cr, Zn and Fe in tissues (liver, ovaries and muscle) of stone loach Noemacheilus barbatulus (L.) living in the Raba River above and below Dobczyce dam reservoir (southern Poland) was determined. The contents of th...

Bergonzini Laurent; Gibert Elisabeth; Winckel Anne; Merdaci Ouassila, 2001: Water and isotope ( (super 18) O and (super 2) H) budgets of Lake Massoko, Tanzania; quantification of the exchange between lake water and ground water. This paper deals with the study of Lake Massoko (9 degrees 20'00S-33 degrees 45'20E, Tanzania), a maar lake of the East-African Rift. Although some water flux of the hydrologic balance of this lake are easily quantified, only the net flu...

Rao, K.V.; Kasiske, B.L.; Bloom, P.M., 1989: Acute graft rejection in the late survivors of renal transplantation. Clinical and histological observations in the second decade. The clinical and histological spectrum of renal allograft rejection occurring in the early posttransplant period is well described, but there is not much information with regard to the nature of graft rejection occurring in the long-term survivors...

Gustafsson, B.E.strom, B.L.ndgren, G.L.fstedt, B., 1979: Working environment in greenhouses. Michigan State University Energy for Agriculture Series ENR: (80-150)

Zazzerini A.; Tosi L., 1987: New sunflower disease caused by fusarium tabacinum. A new disease of sunflower (Helianthus annuus) caused by Fusarium tabacinum was reported from Italy for the first time. All cultivars tested were susceptible to the pathogen. The symptoms, occurring only on stems, consisted of external necrotic st...

Johnston, C.; Bowling, D., 2002: Stability of ascorbic acid in commercially available orange juices. Objective: To compare the vitamin C content of reconstituted frozen orange juice concentrates at preparation to that of ready-to-drink orange juices purchased 4 to 5 weeks from expiration. Design: Juices were unsealed and analyzed for reduced and...

Kanno, Jun, 2003: Reverse toxicology as a future predictive toxicology. Inoue, Tohru [Editor, Reprint Author], Pennie, William D [Editor] Toxicogenomics : 213-218