geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of thioridazine (Mellaril) on titrating delayed matching-to-sample performance of mentally retarded adults


, : Effects of thioridazine (Mellaril) on titrating delayed matching-to-sample performance of mentally retarded adults. American Journal of Mental Deficiency 85(5): 539-547

The effects of thioridazine on the performance of a titrating delayed matching-to-sample discrimination by four retarded adults was investigated. Trials began with the center of three response panels illuminated by one of three colors. The delay between depression of the center response panel and presentation of the two comparison stimuli on the side response panels varied according to the accuracy of the subjects' performance. The primary dependent variable was the limit of delay, defined as the longest delay at which the subject emitted four consecutive correct responses in a 30-minute session. The subjects' chronic doses of thioridazine were reduced systematically in a multiple baseline across-subjects design. For all of the subjects, the limit of delay increased after, and only after, reductions in the daily thioridazine dose had been implemented. Results indicated that the withdrawal of chronically administered thioridazine resulted in increased accuracy in a delayed matching-to-sample task, suggesting strongly that the drug impairs performance of this discrimination.

US$29.90

PMID: 7223785


Other references

Brandt, T.; Juelch, C.; Wasmer, K., 2004: Mueritz national park in Mecklenburg-Vorpommern Der Mueritz-Nationalpark in Mecklenburg-Vorpommern. Falke. Dezember; 5112: 380-382

Wright, D.E.; Forrester, I.T., 1965: Some biochemical effects of sporidesmin. Sporidesmin inhibits in vitro the respiration of guinea pig and sheep liver homogenates in the presence of substrates which require nicotinamide coenzymes for their oxidation. Succinate oxidation was far less sensitive. Similar results were found...

Bloise, E.; Braca, A.; D.T.mmasi, N.; Belisario, M.Antonietta., 2009: Pro-apoptotic and cytostatic activity of naturally occurring cardenolides. Cardenoliddes are steroid glycosides which are known to exert cardiotonic effects by inhibiting the Na(+)/K(+)-ATPase. Several of these compounds have been shown also to possess anti-tumor potential. The aim of the present work was the characteriz...

Paddick R.G.; French F.L., 1968: Some observations on tobacco d yellow dwarf virus control. Australian Tobacco Growers' Bulletin 13: 9-10

Bellanti, J.A.; Russ, S.B.; Holmes, G.E.; Buescher, E.L., 1965: The Nature Of Antibodies Following Experimental Arbovirus Infection In Guinea Pigs. Following experimental infection of guinea pigs with Japanese encephalitis and Russian spring-summer encephalitis viruses, complement-fixing (CF), hemagglutination-inhibiting (HI) and neutralizing (N) antibodies are regularly formed by the 7th to...

Cahu, J.; Surrey, T., 2009: Motile microtubule crosslinkers require distinct dynamic properties for correct functioning during spindle organization in Xenopus egg extract. The organization of the microtubule cytoskeleton depends crucially on crosslinking motors that arrange microtubules in space. Kinesin-5 is such an essential motile crosslinker. It is unknown whether its organizing capacity during bipolar spindle f...

Moynier-Vantieghem, K.; Weber, C.; Espolio, D.Yolanda.; Pautex, S.; Zulian, G., 2010: Demands for death (suicide assistance and euthanasia) in palliative medicine. During a prospective open survey over 12 months of hospitalized patients, 44 death demands were registered for 39 patients (25 cancer, 6 cardiovascular disorder, 2 Parkinson's disease, 3 arthritis, 1 COPD, 1 dementia and 1 severe depression)....

Yan, X.; Liang, L.; Yang, J.; Liu, W.; Ding, X.; Xu, D.; Zhang, Y.; Cui, T.; Yao, J., 2015: Broadband, wide-angle, low-scattering terahertz wave by a flexible 2-bit coding metasurface. Expanding bandwidths and arbitrary control of technology remain key issues in the field of electromagnetic waves, especially in terahertz (THz) wave. In this paper, we propose a novel method to achieve broadband low-scattering THz characteristics...

Lee, A.; Batra, P.; Furer, V.; Cheung, W.; Wang, N.; Franks, A., 2010: Rowell syndrome (systemic lupus erythematosus + erythema multiforme). A 61-year-old woman with a history of chilblains and systemic lupus erythematosus (SLE) for 15 years presented with annular, erythematous, scaly papules and plaques on her face, neck, chest, abdomen, back, arms, and legs. A biopsy specimen showed...

Hadrava, V.; Tremblay, J.; Hamet, P., 1989: Abnormalities in growth characteristics of aortic smooth muscle cells in spontaneously hypertensive rats. Comparative studies have shown that cultured vascular smooth muscle cells from spontaneously hypertensive rats (SHR) proliferate to a higher cell number, grow to a greater density, and have greater specific growth rate, particularly at a higher sa...