geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma


, : Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma. American Journal of Medicine 75(2): 259-262

A group of adults with 76 episodes of acute asthma needing emergency therapy, but not requiring hospitalization, were discharged from an emergency department following standardized therapy with bronchodilators. Upon discharge, the patients were treated with a controlled regimen of oral theophylline, and were randomly assigned in double-blind manner to either a placebo treatment (42 patient episodes) or a corticosteroid treatment group (34 patient episodes). The latter were given an intravenous bolus of methylprednisolone followed by an eight-day tapering course of oral methylprednisolone, starting at 32 mg twice a day. Follow-up was carried out seven or 10 days after treatment in the emergency department. Relapse could not be predicted on the basis of peak expiratory flow rates measured during care in the emergency department. Those patients who received corticosteroids had a decrease in the need for repeated emergency care (5.9 percent versus 21 percent for placebo) and fewer respiratory symptoms (15.6 percent versus 36.4 percent for placebo). It is concluded that a short course of high-dose corticosteroids in outpatients reduces the relapse rate and symptoms following an acute asthmatic attack.

US$29.90

PMID: 6881177


Other references

Nikolaidis, N.M.; Wang, T.C.; Hogan, S.P.; Rothenberg, M.E., 2006: Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lung. Asthma is a complex pulmonary disorder characterized by reversible airflow obstruction, airway hyperresponsiveness, mucus cell metaplasia, and inflammation. Employing animal models of pulmonary inflammation induced by different allergens and Th2...

Elkins, R.C.; Lane, M.M.; Mccue, C., 1999: Ross procedure for ascending aortic replacement. Background. Patients with aortic valve disease and aneurysm or dilatation of the ascending aorta require both aortic valve replacement and treatment of their ascending aortic disease. In children and young adults, the Ross operation is preferred w...

Cipollone, F.; Chiarelli, F.; Iezzi, A.; Fazia, M.L.; Cuccurullo, C.; Pini, B.; De-Cesare, D.; Torello, M.; Tumini, S.; Cuccurullo, F.; Mezzetti, A., 2005: Relationship between reduced Bcl-2 expression in circulating mononuclear cells and early nephropathy in type 1 diabetes. Microalbuminuria is the earliest clinical evidence of diabetic nephropathy, but the mechanisms linking hyperglycemia and kidney complications are not clear. The aim of this study was to evaluate whether enhanced oxidative stress in patients with m...

Castanheira de Oliveira, M.; Prata, C.; Martins, L.Salete.; Dias, Lídio.; Marcelo, F., 2013: Calyceal fistula: a problematic, but treatable, complication of renal transplantation. Calyceal fistula is a rare complication of renal transplantation that may lead to graft loss. This article reports a case of functional recuperation of a graft that seemed condemned to failure. 31 year old male patient, submitted to living donor r...

Asai, T.; Sato, C.; Masani, K.; Usui, M.; Ozawa, M.; Ogino, T.; Aoki, H.; Sawada, T.; Izumiya, H.; Watanabe, H., 2010: Epidemiology of plasmid-mediated quinolone resistance in salmonella enterica serovar typhimurium isolates from food-producing animals in Japan. A total of 225 isolates of Salmonella enterica serovar Typhimurium from food-producing animals collected between 2003 and 2007 were examined for the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants, namely qnrA, qnrB, qnrC,...

Holdgaard, P.Chr.; Nielsen, Søren.Steen.; Wiggers, H.; Bøtker, H.Erik.; Nielsen, T.Toftegård.; Rehling, M., 2007: Chronic ischemic heart failure. Revascularization improves survival among patients with hibernating myocardium. Patients with ischemic heart failure and reversible dysfunctional myocardium (Hibernating myocardium, HIB) can benefit from revascularization. These patients can be selected with nuclear methods. The purpose of this study was to describe the resul...

Glueck, C.J.; Freiberg, R.; Tracy, T.; Stroop, D.; Wang, P., 1997: Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis. In 31 patients with osteonecrosis (primarily of the hip), 74% had 1 or more primary coagulation disorders. In 18 patients, 15 (83%) who had coagulation disorders, the osteonecrosis was initially identified as idiopathic and was not associated with...

Holub, Z.; Vorácek, J.; Roth, J.; Pertl, J.; Lukác, J., 1999: Perioperative hemorrhage associated with laparoscopic hysterectomy: retrospective study. To evaluate perioperative bleeding during laparoscopic hysterectomy. Retrospective clinical study. Department Gynaecology and Obstetrics, Baby Friendly Hospital Kladno, Kladno, Czech Republic. Clinical data and cases of perioperative complications...

Stern B.D.; Ishii N.; Hedgecock E.M.; Culotti J.; Hall D.H., 1987: Three genes act together to guide some migrating cells and axons in caenorhabditis elegans. Society for Neuroscience Abstracts 13(2): 1221

Marabelli, A.; Gambacorta, G., 1967: Hypoglycemic effect of tolbutamide during ether anesthesia. Experimental study. Acta Anaesthesiologica: 71-76