+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Endotoxin-induced release of tumour necrosis factor and interferon in vivo is inhibited by prior adrenoceptor blockade

, : Endotoxin-induced release of tumour necrosis factor and interferon in vivo is inhibited by prior adrenoceptor blockade. Cancer Immunology, ImmunoTherapy 14(1): 41-45

The effect of alpha- and beta-adrenoceptor blocking agents on endotoxin-induced release of tumour necrosis factor (TNF), and of interferon in the circulation of Corynebacterium parvum-treated mice was the subject of this study. TNF was quantified after injection of TNF containing heated serum (TNS) into Meth A sarcoma-bearing mice by determining colour, extent, and incidence of haemorrhagic necrosis. The release of TNF was weakly inhibited by the competitive alpha-blocker phentolamine and the beta-blocker propranolol. The non-competitive alpha-blocker phenoxybenzamine inhibited to a higher degree. Endotoxin-induced elicitation of growth-inhibiting principles into TNS was antagonized by propranolol and phenoxybenzamine. Administration of adrenaline before endotoxin inhibited the elicitation of TNF and growth-inhibitory activities, which indicates tachyphylaxis. The release of interferon was effectively inhibited by both alpha-adrenoceptor blockers but not by propranolol. The interferon was heat-labile. The results indicate that endotoxin-induced TNF and interferon are separate factors, elicited in different ways. As both alpha-blockers do not only inhibit reactions at the alpha-adrenergic receptor but also reactions at the serotonin receptor and in the case of phenoxybenzamine also at the choline receptor, it is suggested that endotoxin-induced release of the anti-tumour factors is controlled by reactions mediated by one or more of these receptors. It is suggested that the inhibition of TNF release by propranolol may be due to the membrane-stabilizing activity of this agent.


PMID: 6186366

Other references

Meyskens, F.L., 2008: Another negative chemoprevention trial: what can we learn?. Clinical Cancer Research 14(1): 2-3

Anker, R.; Steinbrueck, T.; Donis Keller, H., 1992: Tetranucleotide repeat polymorphism at the human thyroid peroxidase locus. Human Molecular Genetics 1(2): 137

Marusik, Yuri, M.; Lehtinen, Pekka, T.; Kovblyuk, Mykola, M., 2004: Cozyptila, a new genus of crab spiders (Aranei: Thomisidae: Thomisinae: Coriarachnini) from the western Palaearctic. A new thomisid genus Cozyptila Lehtinen & Marusik, gen.n. is described with Ozyptila blackwalli Simon, 1875 as its type species. Two new species of this genus are described here from both sexes: C. guseinovorum Marusik & Kovblyuk, sp.n., type loca...

Jacob Klaus, 1993: Competition for the first European geothermal project. Bild der Wissenschaft 1993(3): 15-19

Stanbrook, M.B.; Austin, P.C.; Redelmeier, D.A., 2006: Acronym-named randomized trials in medicine--the ART in medicine study. New England Journal of Medicine 355(1): 101-102

Fredrikson, M.; Sundin, O.; Frankenhaeuser, M., 1985: Cortisol excretion during the defense reaction in humans. Twelve subjects with specific phobias were exposed to slides with a phobic or a neutral content while cortisol excretion, electrodermal activity, and distress-ratings were studied. Six subjects fearful of blood and mutilation, and six of snakes or...

Samii, M.; Migliori, M.M.; Tatagiba, M.; Babu, R., 1995: Surgical treatment of trigeminal schwannomas. A total of 27 patients with trigeminal schwannoma were treated between 1982 and 1992 at the Neurosurgery Department of Nordstadt Hospital. Twelve cases of solitary schwannoma without any family history or physical stigmata of neurofibromatosis wer...

Kampschmidt, R.F.; Pulliam, L.A., 1974: Effect of delayed hypersensitivity on plasma iron and zinc concentration and blood leukocytes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 147(1): 242-244

Sun, M.; Liu, X-Hua.; Wang, K-Ming.; Nie, F-qi.; Kong, R.; Yang, J-song.; Xia, R.; Xu, T-Peng.; Jin, F-Yan.; Liu, Z-Jun.; Chen, J-fei.; Zhang, E-Bao.; De, W.; Wang, Z-Xia., 2014: Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition. Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulation of cellular processes, such as differentiation, proliferation and metastasis. These lncRNAs are found to be dysregulated in a variety of cancers. B...

Miyake, Y.; Shigetoshi, M.; Kojima, M., 1990: Production of highly specific anti-testosterone antiserum by an immunotolerance method. Anti-testosterone antisera were produced by pretreatment of rabbits with 15 alpha-carboxymethyl-5 alpha-dihydrotestosterone linked to a copolymer of D-glutamic acid and D-lysine (D-GL) before immunization with the bovine serum albumin conjugate of...